Non-reproductive actions of sex steroids
著者
書誌事項
Non-reproductive actions of sex steroids
（Ciba Foundation symposium, 191）
Wiley, 1995
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注記
"Symposium on Non-Reproductive Actions of Sex Steroids, held at the Ciba Foundation, London, 30 August-1 September 1994"--Contents p
Editors: Gregory R. Bock and Jamie A. Goode
Includes bibliographical references and indexes
内容説明・目次
内容説明
Sex steroids have a number of physiological effects in addition to their classical sex-related roles. This book brings together clinicians and basic researchers from a number of disciplines to discuss the non-reproductive actions of sex steroids. In many instances, sex steroids mediate the expression of a variety of genes by influencing the activity of intracellular receptors, which in turn bind to hormone response elements in the promoters of hormone-regulated genes. Direct membrane-mediated effects have also been described. Sex steroids have numerous effects on the brain, and although many of these are directed to neural functions underlying reproduction, others are more broadly related to brain function. Among these are effects on cognitive function, motor coordination (high levels of oestrogen exacerbate symptoms of Parkinson's disease), depressive illness and dementia (oestrogen has been shown to improve cognitive function in Alzheimer's disease patients). Neurosteroids also have an important role in nerve repair. The protective role of oestrogen against cardiovascular disease in women is widely documented: the mechanism behind this cardioprotective effect is discussed.
The incidence of autoimmune disease is higher in women than in men, and oestradiol appears to exacerbate the symptoms of many of these diseases, with the exception of rheumatoid arthritis, where oestrogen suppresses symptoms. The effects of sex steroids on the immune system are therefore covered in the book. Sex steroids have been implicated in the pathogenesis of several types of cancers. Synthetic steroid antagonists, such as tamoxifen, have been widely studied as therapeutic agents for hormone-dependent cancers. Hormone replacement therapy (HRT) has been shown to have a number of beneficial effects. In particular, HRT reduces postmenopausal demineralization of bone, thus slowing the advance of osteoporosis. Protective effects of HRT on cardiovascular disease have also been reported. The advantages and disadvantages of HRT therefore form a major topic of discussion in the book.
目次
- Transcriptional Control by Steroid Hormones: the Role of Chromatin
- Non-Genomic Mechanisms of Action of Steroid Hormones
- Oestrogens and the Structural and Functional Plasticity of Neurons: Implications for Memory, Ageing and Neurodegenerative Processes
- Actions of Sex Steroids on Behaviours Beyond Reproductive Reflexes
- Neurosteroids: Synthesis and Functions in the Central and Peripheral Nervous Systems
- Oestrogen Synthesis, Oestrogen Metabolism and Functional Oestrogen Receptors in Bovine Aortic Endothelial Cells
- Oestradiol Inhibition of Vascular Myointimal Proliferation Following Immune, Chemical and Mechanical Injury
- Hormone Replacement Therapy and Cardiovascular Disease: the Case for a Randomized Controlled Trial
- Symptoms Related to the Menopause and Sex Steroid Treatments
- Sex Steroids, Cytokines and the Bone Marrow: New Concepts on the Pathogenesis of Osteoporosis
- Sex Steroids and the Immune System
- Steroidal Regulation of Cell Cycle Progression
- Surprises with Antiprogestins: Novel Mechanisms of Progesterone Receptor Action
- Oestrogen- and Anti-Oestrogen-Regulated Genes in Human Breast Cancer
- Human Prostate Cancer: a Direct Role for Oestrogens.
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