HIV and dementia : proceedings of the NIMH-Sponsored Conference "Pathogenesis of HIV infection of the brain : impact on function and behavior"
著者
書誌事項
HIV and dementia : proceedings of the NIMH-Sponsored Conference "Pathogenesis of HIV infection of the brain : impact on function and behavior"
(Current topics in microbiology and immunology, 202)
Springer-Verlag, c1995
大学図書館所蔵 全14件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
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  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
The National Institute of Mental Health (NIMH) AIDS Program is the fourth largest acquired immune deficiency syndrome (AIDS) program within the National Institutes of Health (NIH). Since 1983, our program's contributions have concentrated on two major areas. The first has been to develop effective strategies to prevent or reduce behaviors that place individuals at risk for human immunodeficiency virus type 1 (HIV-1) infection. The second has been to support and foster research to enhance our understanding of the profound impact of H IV-1 infection on the central nervous system (eNS). The brain appears to be a prime target of the virus and may serve as a reservoir for the virus. Post mortem examination of brain tissue has provided evidence of eNS cell damage in 80%-90% of people who die with AIDS. For about 10%-20% of people with AI DS, mild neuropsychological symptoms are the first signs of the disease. Approximately 20% of individuals infected with HIV-1 develop AIDS dementia complex. The symptoms include apathy, difficulty concentrat- ing, irritability, depression, and personality changes. In the later stages of the disease, people may experience psychiatric disor- ders.
Death usually occurs within 6 months of the appearance of those more severe symptoms. Up to 90% of children infected with H IV-1 experience attention and concentration difficulties and often experience neurodevelopmental delay or regression over time.
目次
List of Contents.- A The Human Problem: HIV, Neuropsychiatric Disorders, and Dementia.- The Pathogenesis of HIV Infections of the Brain.- Neurocognitive Disorders in HIV-1 Infection.- AIDS Dementia Complex and HIV-1 Brain Infection: A Pathogenetic Framework for Treatment and Evaluation.- Quantitative Neuropathologic Assessment of HIV-1 Encephalitis.- Penetration of Solutes, Viruses, and Cells Across the Blood-Brain Barrier.- Cytotoxic T Lymphocytes and HIV-1-Related Neurologic Disorders.- Distinct HIV-1 env Sequences Are Associated with Neurotropism and Neurovirulence.- Role for Astrocytosis in HIV-1-Associated Dementia.- Therapeutic Approaches to HIV Infection Based on Virus Structure and the Host Pathogen Interaction.- B Lentivirus Animal Models of HIV Central Nervous System Disease.- Neurobiology of Simian and Feline Immunodeficiency Virus Infections.- Selected Models of HIV-Induced Neurological Disease.- Feline Immunodeficiency Virus as a Model for Study of Lentivirus Infection of the Central Nervous System.- Transgenic Models to Assess the Neuropathogenic Potential of HIV-1 Proteins and Cytokines.- C Tissue Culture and Animal Models to Generate Basic Concepts in Viral Immune Cell: Central Nervous System Interactions.- Virus Entry and Release in Polarized Epithelial Cells.- Traffic of Hematogenous Cells Through the Central Nervous System.- Principles of Cytotoxic T Lymphocyte Induction and Recognition.- Virus-Neuron-Cytotoxic T Lymphocyte Interactions.
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