The Legacy of cell fusion
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書誌事項
The Legacy of cell fusion
Oxford University Press, 1994
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内容説明・目次
内容説明
The powerful method of viral-induced fusion of animal cells was invented by Henry Harris and his colleagues in 1965, in order to study the genetics of somatic animal cells. This volume evaluates the impact of cell hybridization on the study of cell differentiation, gene mapping, gene regulation, and the development of monoclonal antibodies. Studies are presented on nuclear structure and function, intracellular transport, membrane protein mobility, and
nuclear-cytoplasmic interactions in heterokaryons and other cells. Early experiements by Harris and co-workers suggested that gene loss plays an important role in tumour formation and that the malignant phenotype could be suppressed by hybridization with non-malignant cells. This principle has since been shown
to apply to a wide range of natural and experimental tumours, in species ranging from Drosophila to man. Tumour-suppressor genes are discussed, together with the role of radiation-hybrid mapping in the analysis of genetic tumours.
The volume concludes with an article in which Henry Harris sums up some of the unsolved questions that remain to be studied in the link between cell growth and differentiation. This volume aims to celebrate the legacy of cell fusion in its proper perspective.
目次
- 1. Heterokaryons reveal that differentiation requires continuous regulation
- 2. The instability of differentiation in hepatomas
- 3. Nuclear protein sorting in heterokaryons and homokaryons
- 4. Some insights into the replication of damaged DNA in mammalian cells
- 5. The role of the nucleolus in the transfer of information from nucleus to cytoplasm
- 6. Transcription by immobile RNA polymerases
- 7. Lateral mobility of membrane proteins - a journey from heterokaryons to laser tweezers
- 8. Intracellular transport of secretory proteins within intact transient heterokaryons and homokaryons
- 9. Radiation hybrid mapping: an idea whose time has finally arrived
- 10. The cloning of tumour suppressor genes
- 11. The road to monoclonal antibodies
- 12. The genetic analysis of human cancer
- 13. Genes in control of cell proliferation and tumorigenesis in Drosophila
- 14. Genetics and molecular biology of tumour formation in Xiphophorus
- 15. Loss of function mutations in human cancer
- 16. Cancer suppression by the retinoblastoma gene
- 17. The p53 pathway: past and future
- 18. Somatic cell genetics and the search for colon cancer genes
- 19. Roles of the myc gene in cell proliferation and differentiation, as deduced from its role in tumorigenesis
- 20. Genes that suppress the action of mutated ras genes
- 21. Unfinished business
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