Hormones and aging

著者

書誌事項

Hormones and aging

edited by Paola S. Timiras, Wilbur B. Quay, Antonia Vernadakis

CRC Press, c1995

大学図書館所蔵 件 / 全7件

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Hormones and Aging describes changes with aging in a wide spectrum of secretory functions including: Hormones from classical endocrine glands and hormone-like secretions Chemical mediators from diffuse cells within several systems, particularly the nervous and the immune systems The book is comprised of three parts. The first reviews changes in hormonal functions that occur in humans from youth to old age under conditions of normal aging. It focuses on the menopause, changes in body composition and muscle mass, decline in metabolic rate, and alterations of oxidative metabolism. The second part examines the pathological consequences of aging associated hormonal changes. It focuses on diabetes, osteoporosis, altered responses to stress, and cancer. The pathophysiology of these diseases is evaluated in the light of state-of-the-art biomedical advances, including molecular and genetic advances. Major preventive and therapeutic interventions are outlined, in particular the role of hormonal replacement therapy, growth promoting and cancer inhibiting substances, and influence of nutrition. The third part discusses the relation of hormones to other systems, such as the nervous and immune systems, and their implications for the etiology of the aging process itself. It focuses on neuroendocrine and immunoendocrine theories of aging, molecular mechanisms of senescent cell responses, and receptor responses. The book primarily considers humans, but also provides in vivo studies from uni- and pluri-cellular complex animal organisms, as well as from cultured cells in vitro. Contributors provide a lucid, easily understood, and well-organized text that presents a concise review of a large variety of topics, integrating basic and clinical information. It also contains 141 illustrations and tables. Hormones and Aging represents a timely and useful contribution to a rapidly expanding field of chemical mediators and aging.

目次

Introduction Aging: Definitions, Demography, Evolution, and Theories, P.S. Timiras Aging of the Endocrine Glands Steroid-Secreting Endocrines: Adrenal, Ovary, Testis, P.S. Timiras Protein- and Peptide-Secreting Endocrines, P.S. Timiras Amine-Secreting Endocrines, W.B. Quay and T. Kachi Hormones of the Thyroid and Parathryoid Glands, P.S. Timiras Diffuse Endocrines and Chemical Mediators, W.B. Quay Aging of the Female Reproductive System, J. Sentenac and P.S. Timiras The Menopause: Clinical Aspects and Current Trends in Therapy, P.S. Timiras and J. Sentenac Reproductive Hormonal Changes in the Aging Male, F.E. Kaiser and J.E. Morley Pathology and Hormonal Action in the Aged Regulation of Nutrient Metabolism, W.B. Quay An Overview of the Pathogenesis and Management of Non-Insulin Dependent Diabetes Mellitus, W.C. Duckworth Clinical and Metabolic Aspects of Nutrition and Aging, R.C. Casper and C.H. Winograd Osteoporosis: Pathogenesis, Diagnosis, and Treatment, C.Y.C. Pak Stress, Glucocorticoids, and Aging, L. Goya, F. Rivero, and A.M. Pascual-Leone Molecular Regulatory Mechanisms Cellular and Molecular Basis of Aging, S.I.S. Rattan Effects of Hormones on Neural Tissue: In Vivo and In Vitro Studies, A. Vernadakis Oxidative Stress and Loss of Receptor Sensitivity in Aging, J.A. Joseph and R. Villalobos-Molina Growth Factors and Steroids in Normal and Abnormal Cell Proliferation, G.L. Firestone, A.C. Maiyar, and R.A. Ramos Mechanism of Altered Target Cell Response, T. Fuloep and E.M. Dax Aging and Defense Mechanisms: The Immune System, F. Homo-Delarche, R. Goya, J.-F. Bach, and M. Dardenne Conclusions and Perspectives Neuroendocrinological Theories of Aging, P.S. Timiras

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