Growth factors and tumor promotion : implications for risk assessment : proceedings of the Seventh International Conference on Carcinogenesis and Risk Assessment, held in Austin, Texas, on December 1-4, 1993
著者
書誌事項
Growth factors and tumor promotion : implications for risk assessment : proceedings of the Seventh International Conference on Carcinogenesis and Risk Assessment, held in Austin, Texas, on December 1-4, 1993
（Progress in clinical and biological research, v. 391）
Wiley-Liss, c1995
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This study analyzes and compares available data on the role of growth factors and tumour promoters in tumour development in both experimental animal models and humans. Emphasis is placed on the biological, cellular and molecular changes that occur under the influence of growth factors and tumour promoters during tumour development. The contributors identify the possible importance of these factors to human cancer risk assessment. In addition, special attention is given to certain tumour promoters for which human case studies are available for comparison.
目次
- Skin Carcinogenesis: Characteristics, Mechanisms and Prevention
- The Instability of Tumour Promotion in Relation to Human Cancer Risk
- A Decision Tree Approach for Carcinogen Risk Assessment
- Hypomethylation of DNA: A Possible Epigenetic Mechanism Involved in Tumour Protection
- The Tumour Promotor Receptor Protein Kinase C: A Novel Target for Chemoprevention and Therapy of Human Colon Cancer
- Transforming Growth Factors in Mammary Tumourigenesis: Promotors or Antipromotors?
- The Pro-Inflammatory and Hyperplasiogenic Action of Interleukin-1 in Mouse Skin
- Hormonal and Genetic Interactions in Murine Hepatocarcinogenesis
- Hepatocarcinogenesis in Transgenic Mice
- Saccharin-Induced Bladder Cancer in Rats
- Phenobarbital Mouse Liver Tumours: Implications of Hepatic Tumour Protection for Cancer Risk Assessment
- The Use of Biological Data in Addition to the Carcinogen Bioassay in Quantitative Risk Assessment
- The Potential Role of Oxidative Stress in Nongenotoxic Carcinogenesis in the Mouse Liver
- Modulation of Gap Junctional Intercellular Communication by Phosphorylation: Effects of Growth Factors, Kinase Activators, and Phosphatase Inhibitors
- Incorporating the Concept of Invaders and Defenders in the Dose-Response Modelling of Carcinogens.
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