Angiotensin II receptors
著者
書誌事項
Angiotensin II receptors
（Pharmacology & toxicology）
CRC Press, c1994
- v. 2
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注記
Includes bibliographical references and index
収録内容
- v. 1. Molecular biology, biochemistry, pharmacology, and clinical perspectives
- v. 2. Medicinal chemistry
内容説明・目次
- 巻冊次
-
ISBN 9780849383809
内容説明
This unique reference set provides a broad-based, in-depth presentation on angiotensin II receptors, from the genes that encode them to the responses they mediate in humans. The books emphasize known and potential therapeutic applications of the antagonists of angiotensin II receptors and the angiotensin-converting enzyme inhibitors. The molecular biology of angiotensin II receptors is reviewed, as are the biochemical effects mediated by angiotensin II receptors.
This is the first publication to analyze in detail the structure-activity relationships for both peptide and nonpeptide angiotensin II receptor agonists and antagonists. It also presents the pharmacological effects mediated by angiotensin II receptors both in the periphery and in the brain.
目次
Introduction: Angiotensin II Receptors, D.P. Brooks and R.R. Ruffolo, Jr.
Angiotensin II Receptor Subclassification, R.M. Edwards and R.R. Ruffolo, Jr.
Molecular Biology of Angiotensin II Receptors, D.J. Bergsma
Angiotensin II Receptor Signal Transduction Mechanisms, R.M. Edwards and R.R. Ruffolo, Jr.
Functions Mediated by Peripheral Angiotensin II Receptors, D.P. Brooks and R.R. Ruffolo, Jr.
Functions Mediated by Angiotensin II Receptors in the Brain, D.P. Brooks and R.R. Ruffolo, Jr.
Therapeutic Applications of Angiotensin II Antagonists, M.I. Freed, B.E. Ilson, N.H. Shusterman, and D.K. Jorkasky
- 巻冊次
-
v. 2 ISBN 9780849385452
内容説明
This unique reference set provides a broad-based, in-depth presentation on angiotensin II receptors, from the genes that encode them to the responses they mediate in humans. The books emphasize known and potential therapeutic applications of the antagonists of angiotensin II receptors and the angiotensin-converting enzyme inhibitors. The molecular biology of angiotensin II receptors is reviewed, as are the biochemical effects mediated by angiotensin II receptors.
This is the first publication to analyze in detail the structure-activity relationships for both peptide and nonpeptide angiotensin II receptor agonists and antagonists. It also presents the pharmacological effects mediated by angiotensin II receptors both in the periphery and in the brain.
目次
Introduction: Medicinal Chemistry of Angiotensin II Receptors, J. Gleason and R.R. Ruffolo, Jr.
Structure-Activity Relationships of Peptide Angiotensin II Receptor Agonists and Antagonists, J. Samanen and D. Regoli
Conformational Models of Angiotensin II for Nonpeptide Antagonist Design, J. Samanen, J. Hempel, R. Keenan, C. Peishoff, and J. Weinstock
Structure Activity Relationships of Nonpeptide Angiotensin II Receptor Antagonists, J. Weinstock and R.M. Keenan
Index
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