Camptothecins : new anticancer agents

著者

書誌事項

Camptothecins : new anticancer agents

edited by Milan Potmesil and Herbert Pinedo

CRC Press, c1995

大学図書館所蔵 件 / 全2件

この図書・雑誌をさがす

注記

Includes bibliographical references and index

内容説明・目次

内容説明

This exciting new book presents the first comprehensive overview of clinical trials of camptothecins, a new class of anticancer agents. Camptothecins are synthetic and semisynthetic derivatives of a plant alkaloid that inhibit a cellular enzyme and trigger a cascade of events leading to programmed cell death. Special attention is given to the adverse effects of camptothecin treatment, as well as to prevention and control. The book boasts contributions by some of the most respected authorities in camptothecin research, who have Conducted much of the pre-clinical work which helped to renew interest in camptothecins Discovered and identified the natural product camptothecin and synthesized most of the anlogues Discovered the mechanism of camptothecin cytotoxicity

目次

Introduction, M. Potmesil and H.M. Pinedo Biochemistry of Camptothecin, L.F. Liu Camptothecin and Analogues: From Discovery to Clinic, M.E. Wall and M. Wani Twenty Years Later: Review of Clinical Trials with Camptothecin Sodium (NSC-100880), F. Muggia Preclinical Development of 20(S)-Camptothecin, 9-Aminocamptothecin and Other Analogues, M. Potmesil and B.C. Giovanella Phase I Clinical Trial and Pharmacokinetic Results with Oral Administration of 20(S)-Camptothecin, J.S. Stehlin, E.A. Natelson, H.R. Hinz, B.C. Giovanella, P.D. de Ipolyi, K.M. Fehir, T.P. Trezona, D.M. Vardeman, N.J. Harris, A.K. Marcee, A.J. Kozielski, and A. Ruiz-Razura Clinical Studies of CPT-11 in Japan, T. Taguchi Clinical Trials and Pharmacokinetic Studies of CPT-11 in the United States, M.L. Rothenberg, E.K. Rowinksy, J.G. Kuhn, H.A. Burris, III, R.C. Donehower, and D.D. Von Hoff CPT-11: Clinical Trials and Pharmacology Studies of CPT-11 and its Active Metabolite SN-38 in France: Preliminary Pharmacokinetic-Pharmacodynamic Relationships, G.G. Chabot, M. de Forni, D. Abigerges, J.-.P Armand, M. Clavel, R. Bugat, S. Culine, J.-M. Extra, M. Marty, M.-C. Bissery, A. Mathieu-Boue, P. Herait, and A. Gouyette Topotecan Clinical Trials in the United States, H. Hochster Clinical Trials of Topotecan in Europe, J. Verweij, W.T.B. Huinink, B. Lund, A. Planting, J. Beijnen, M. de Boer-Dennert, H. Rosing, I. Koier, and H. Hansen Camptothecins: Dose-Limiting Toxicities and their Management, H.A. Burris, III, S.M. Fields, J.G. Kuhn, and D.D. Von Hoff Cellular Determinants of Sensitivity and Resistance to Camptothecins, Y. Pommier, A. Tanizawa, K. Okada, and T. Andoh The Perspectives, M. Potmesil and H.M. Pinedo

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