Thrombin : its key role in thrombogenesis : implications for its inhibition clinically
著者
書誌事項
Thrombin : its key role in thrombogenesis : implications for its inhibition clinically
CRC Press, c1995
大学図書館所蔵 全3件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
This new multi-authored book reviews the current understanding of the role of thrombin in venous and arterial thrombosis and its inhibition in the clinical setting. Heparin, the most widely used antithrombotic, does not effectively regulate thrombin or its formation. Accumulating evidence suggests that other antithrombins are effective in some of the situations where heparin is not. Discussions include the current knowledge on antithrombotic prophylaxis and therapy, from the perspective of the role in thrombin in venous and arterial vascular disease, the limitations of the current anticoagulant therapies, and potential and limitations of newer antithrombins currently being tested in several experimental and clinical settings. Thrombin helps the clinician to better rationalize the use of specific antithrombins in the prevention and management of thrombotic disease and provides the basic scientist with a better understanding of the goals the clinician attempts to achieve with antithrombotic therapy.
目次
Thrombin-Catalyzed Amplification and Inhibitory Reactions of Blood Coagulation, F.A. Ofosu, M.R. Buchanan, and S.J. Brister
Introduction
Acceleration of Blood Coagulation
Summary
The Structural Basis for Thrombin Inhibition by Hirudin and Serpins, M.T. Stubbs and W. Bode
Introduction
Thrombin Structure and Its Sites of Interaction
Interaction with Fibrinogen
Interaction with Hirudin
Interaction with Serpins
Summary
Development and Rationale for the Use of Low Molecular Weight Heparins in the Prevention and Treatment of Venous Thrombosis, J.R. Leclerc
Introduction
Unfractionated Heparin
Low Molecular Weight Heparins
Mechanism of Action
Advantages of Low Molecular Weight Heparin
Clinical Studies
Heparin Cofactor II and the Prevention and Treatment of Thrombosis, M.R. Buchanan, S.J. Brister, and F.A. Ofosu
Introduction
Why Target Thrombin for Inhibition?
The Basis for Antithrombotic Therapy
Inhibition of Surface-Bound Thrombin
Thrombin HCII Inhibition
Inhibition of Thrombin by Heparin Cofactor II: Effect on Thrombus Formation/Growth in the Experimental Setting
Conclusion
Future Directions
Development and Rationale for the Use of Direct Thrombin Inhibitors in the Prevention and Treatment of Arterial and Venous Thrombosis, J.S. Ginsberg
Introduction
Clinical Studies of Direct Thrombin Inhibitors
Development and Rationale for Use of Anti-Thrombins in Arterial Thrombosis, S.J. Brister, F.A. Ofosu, and M.R. Buchanan
Introduction
The Prothrombotic State
Regulation of the Prothrombotic State
Conclusion
Pediatric Thromboembolism: Epidemiology, Prevention and Treatment, M. Andrew and M. David
Introduction
The Relationship Between Age and the Occurrence of DVT/PE
Mechanisms Protecting Children from Thromboembolic Complications
The Epidemiology of DVT/PE in Children
Clinical Outcome
Conclusion
The Role of Thrombin Inhibition in Thrombolytic Therapy, M. Pr
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