Prions prions prions
著者
書誌事項
Prions prions prions
（Current topics in microbiology and immunology, 207）
Springer-Verlag, c1996
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内容説明・目次
内容説明
A series of remarkable discoveries in the past three decades have led to the molecular and genetic characterization of the transmissible pathogen causing scrapie in animals and a quartet of human illnesses: kuru, Jakob-Creutzfeld disease, Gerstmann-Straussler-Scheinker disease, and fatal familial insomnia. To distinguish this pathogen from viruses and viroids, the term "prion" was introduced to emphasize its proteinaceous and infectious nature. Stanley B. Prusiner, editor of this volume, was awarded the 1997 Nobel Prize in Physiology and Medicine for his pioneering discovery of prions. The book reviews advances in studies of prions, which - as considereable evidence indicates - are novel pathogens composed only of protein.
目次
List of Contents.- Human Prion Diseases and Neurodegeneration.- Fatal Familial Insomnia and Familial Creutzfeldt-Jakob Disease: A Tale of Two Diseases with the Same Genetic Mutation.- Human Prion Disease and Human Prion Protein Disease.- Prion Strains.- Structures of Prion Proteins and Conformational Models for Prion Diseases.- The Folding Intermediate Concept of Prion Protein Formation and Conformational Links to Infectivity.- Cell Biology of the Prion Protein.- Transgenetics and Gene Targetting in Studies of Prion Diseases.- Transgenetics and Neuropathology of Prion Diseases.- Evidence for Two Prions in Yeast: [URE3] and [PSI].
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