Telomeres
著者
書誌事項
Telomeres
（Cold Spring Harbor monograph series, 29）
Cold Spring Harbor Laboratory Press, 1995
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Research on telomeres has recently surged forward. Telomeres have been found to shorten in neoplastic and aging cells, and their analysis has been stimulated by the molecular cloning of key components in telomere metabolism. This book offers a comprehensive account of telomere structure and function in a variety of organisms, including yeast, Drosophila, ciliates, plants and mammals. Starting with a historical overview, it covers telomere structure, dynamics, localization, transcriptional silencing, as well as the significance of length regulation and the roles of telomeres. Written and edited by members of leading laboratories, the book should be of use to investigators of cancer and aging, as well as those with interests in replication, ribonuclear particles, chromosome dynamics and polymerases.
目次
- Beginning of the end - origins of the telomere concept, J.G. Gall
- telomere DNA structure, E. Henderson
- telomerase biochemistry and regulation, C.W. Greider
- telomere proteins, G. Fang, T.R. Cech
- saccharomyces telomeres - function, structure and replication, V.A. Zakian
- telomere position effects and transcriptional silencing in the yeast saccharomyces cerevisiae, D. Shore
- developmentally programmed healing of chromosomes, E.H. Blackburn
- non-programmed and engineered chromosome breakage, H. Cooke
- telomeres and ageing, C.B. Harley
- telomere dynamics and genome instability in human cancer, T. de Lange
- cytology of telomeres, A.F. Dernburg, et al
- Drosophila telomeres - another way to end it all, M.L. Pardue
- plant telomeres, E.J. Richards.
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