Virology and immunology
Author(s)
Bibliographic Information
Virology and immunology
（The practical approach series, v. 156 . HIV : a practical approach ; v. 1）
IRL Press at Oxford University Press, c1995
1st ed
- : hbk.
- : pbk.
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Note
Includes bibliographical references and index
Description and Table of Contents
- Volume
-
: pbk. ISBN 9780199634927
Description
AIDS is one of the most pressing medical emergencies of our era. Despite arguments to the contrary, the majority of AIDS researchers have agreed that there is a causal link between HIV infections and AIDS. However, it is now 12 years since the discovery of HIV and we are still a long way from understanding and controlling AIDS HIV 1 and HIV 2 are guides to studying HIV in the laboratory. HIV 1 describes studies of the virus and infected cells and covers techniques
for handling HIV safely, for studying viral entry, replication, and neutralization, and basic immunological techniques. HIV 2 explores the biochemistry and molecular biology of HIV, with a section on recent approaches to drug discovery.
HIV research is highly multidisciplinary so a complete compendium of all related methods would have been unreadable. Instead, these two volumes focues on the specialized techniques which are unique to studies of HIV. The books have been designed so that a novice entering HIV research can find clear instructions about how to perform standard experiments, such as assays for reverse transcriptase or antibodies to HIV. In addition the books include many novel methods which are described in
detail for the first time.
Table of Contents
- Section 1: Growth and isolation of HIV
- 1. Biological safety when working with HIV
- 2. Virological and molecular genetic techniques for studies of established HIV isolates
- 3. Isolation and biological characterization of primary HIV isolates
- 4. HIV infection of macrophages
- 5. HIV infection of dendritic cells
- 6. Vectors based on HIV
- Section 2: Analysis of HIV infection
- 7. Quantitative assays for virus neutralization
- 8. Detection of HIV entry into cells
- 9. Detection of viral DNA by PCR
- 10. Detection of viral RNA by PCR
- 11. Sequence analysis of virus variability based on PCR
- Section 3: Immunology
- 12. Humoral responses and detection during HIV infection
- 13. Quantification of CD4-positive T lymphocytes
- 14. CD-4 positive T-cell responses in HIV-1 infection
- 15. Lymphokine responses to HIV infection
- 16. HIV-1 specific cytotoxic T-lymphocyte responses and ADCC
- Volume
-
: hbk. ISBN 9780199634934
Description
AIDS is undeniably one of the most pressing medical emergencies of our era. It is now 12 years since the discovery of HIV and in spite of a world-wide research effort no proven method for controlling AIDS has been developed. HIV Volumes 1 and 2 are guides to studying HIV in the laboratory focusing on specialized techniques unique to this field. Both books provide the novice entering HIV research with clear instructions on how to perform standard experiments as well as including many novel methods described in detail for the first time. Volume 1 describes studies of the virus and infected cells and covers techniques for handling HIV safely, for studying viral entry, replication and neutralization and basic immunological techniques. This book is intended for these books provide instructions in virological, biochemical, molecular biological, and immunological methods of use for HIV researchers in academic institutions, medical schools, and the pharmaceutical industry.
Table of Contents
Section 1: Growth and isolation of HIV. 1.: Biological safety when working with HIV. 2.: Virological and molecular genetic techniques for studies of established HIV isolates. 3.: Isolation and biological characterization of primary HIV isolates. 4.: HIV infection of macrophages. 5.: HIV infection of dendritic cells. 6.: Vectors based on HIV. Section 2: Analysis of HIV infection. 7.: Quantitative assays for virus neutralization. 8.: Detection of HIV entry into cells. 9.: Detection of viral DNA by PCR. 10.: Detection of viral RNA by PCR. 11.: Sequence analysis of virus variability based on PCR. Section 3: Immunology. 12.: Humoral responses and detection during HIV infection. 13.: Quantification of CD4-positive T lymphocytes. 14.: CD-4 positive T-cell responses in HIV-1 infection. 15.: Lymphokine responses to HIV infection. 16.: HIV-1 specific cytotoxic T-lymphocyte responses and ADCC
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