In vitro aspects of erythropoiesis

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In vitro aspects of erythropoiesis

edited by Martin J. Murphy, Jr. ; co-editors, Cesare Peschle ...[et al.]

Springer-Verlag, c1978

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Includes bibliographical references and index

内容説明・目次

内容説明

vitro methodology for the cultivation of erythroid The purpose of In Vitro Aspects of Erythropoiesis is to broaden our understanding of the regulation of stem cells. The second series of papers treats cellular normal and neoplastic hematopoietic cells by means and soluble factors which affect erythroid stem cell of a synthesis of different techniques, divergent no- differentiation. Hormonal modulation of in vitro menclature as well as a closer standardization of re- erythropoiesis is the theme of the third session fol- agents and methods which had heretofore produced lowed by a series of papers in the fourth which fo- vagaries of results among different laboratories. cuses on erythropoiesis after transformation by ei- Hence the papers, discussions and appendices pre- ther Friend or Rauscher viruses. The fifth session deals with serum inhibitors to erythropoiesis and the sented in this volume will be of value and interest to investigators and clinicians as well as to students and role of the macrophage in red blood cell production. teachers of hematology. Finally, the sixth session concentrates on the biogen- In Vitro Aspects of Erythropoiesis is comprised of esis of erythropoietin in vivo and in vitro. thirty papers delivered by twenty invited contribu- Each of the six sections is followed by a discus- tors at a three day conference which was held in sion which was transcribed and initially edited at the Capri, Italy in October of 1977. The contributors meeting.

目次

1. Erythropoiesis In Vitro: A Brief Introduction.- 2. Erythropoietin-Independence of Early Erythropoiesis and a Two-Regulator Model of Proliferative Control in the Hemopoietic System.- 3. In Vitro Modulation of Human Erythropoiesis by Lymphocyte-Rich Fractions of Blood.- 4. Cryogenic Preservation of Human and Murine Erythropoietic and Granulopoietic Colony-Forming Cells.- 5. Miniaturization of Methylcellulose Erythroid Colony Assay.- 6. Culture Systems In Vitro for the Assay of Erythrocytic and Megakaryocytic Progenitors.- Discussion (Chapters 1-6).- 7. Cellular and Soluble Factors Influencing the Differentiation of Primitive Erythroid Progenitor Cells (BFU-e) In Vitro.- 8. The Effect of Sustained Hypertransfusion on Hematopoiesis.- 9. Inhibitors of Erythropoiesis: Effects of Red Cell Extracts on Heme Synthesis and Erythroid Colony Formation in Human Bone Marrow Cultures.- 10. Production of Erythroid Precursor Cells in Long-Term Culture of Mouse Bone Marrow Cells.- 11. Production of Erythroid Precursor Cells (BFU) In Vitro.- Discussion (Chapters 7-11).- 12. Hormonal Modulation of Erythropoiesis In Vitro.- 13. Regulatory Mechanisms of Erythroid Stem Cell Kinetics.- 14. Hormonal Influences on Erythroid Colony Growth in Culture.- 15. A Lack of Burst-Forming Unit (BFU-e) and Lymphocyte-Mediated Suppression of Erythropoiesis in Patients with Aplastic Anemia.- 16. Pharmacological Agents and Erythroid Colony Formation: Effect of Beta-Adrenergic Agonists and Steroids.- 17. In Vitro Assessment of Similarities between Erythroid Precursors of Fetal Sheep and Patients with Polycythemia Vera.- Discussion (Chapters 12-17).- 18. Murine Erythroleukemia: Cell Surface and Cell Cycle-Related Events of Induced Differentiation.- 19. Regulation of Heme Biosynthesis in Mouse Friend Virus-Transformed Cells in Culture.- 20. Comparative Studies on Hemopoietic Stem Cell Pools in Mice after Friend (FV-P) or Rauscher Virus Infection.- 21. Studies on Erythroid Differentiation in a Wild-Type and Dimethylsulfoxide-Resistant Clone of Friend Virus-Transformed Cells: Effects of Hemin, Hemoglobin, and Erythropoietin.- 22. Induction of Uroporphyrinogen-1 Synthase Activity in Mitogen-Stimulated Lymphocytes: Deficient Induction in Acute Intermittent Porphyria Cells.- 23. Potential for Differentiation, Virus Production, and Tumorigenicity in Murine Erythroleukemic Cells Treated with Interferon.- 24. Kinetics of Erythroid and Myeloid CFU Following Rauscher Virus Infection.- Discussion (Chapters 18-24).- 25. The Role of Serum Inhibitors of Erythroid Colony-Forming Cells in the Mechanism of the Anemia of Renal Insufficiency.- 26. Modulatory Effect of Macrophages on Erythropoiesis.- Discussion (Chapters 25-26).- 27. Extrarenal Erythropoietin.- 28. In Vitro Aspects of Erythropoietin Production.- 29. Renal and Extrarenal Erythropoietin Production in Anemia.- 30. Recent Advances in Erythropoietin Physiology.- Discussion (Chapters 27-30).- Appendices 1-13.

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