Genetic manipulation of the nervous system
著者
書誌事項
Genetic manipulation of the nervous system
(Neuroscience perspectives)
Academic Press, c1996
大学図書館所蔵 全8件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences.
Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.
The recent development of Gene Therapy procedures which allow specific genes to be delivered to human patients who lack functional copies of them is of major therapeutic importance. In addition such gene delivery methods can be used in other organisms to define the function of particular genes. These studies are of particular interest in the nervous system where there are many incurable diseases like Alzheimer's and Parkinson's diseases which may benefit from therapies of this kind. Unfortunately gene delivery methods for use in the nervous system have lagged behind those in other systems due to the fact that the methods developed in other systems are often not applicable to cells like neurons which do not divide. This book discusses a wide range of methods which have now been developed to overcome these problems and allow safe and efficient delivery of particular genes to the brain. Methods discussed include virological methods, physical methods (such as liposomes) and the transplantation of genetically modified cells. In a single volume therefore this book provides a complete view of these methods and indicates how they can be applied to the development of therapies for treating previously incurable neurological disorders.
目次
Genetic Manipulation of the Nervous System: An Overview. Non-Neurotropic Adenovirus: A Vector for the Gene Transfer to the Brain and Possible Gene Therapy of Neurological Disorders. Adenovirus: A New Tool to Transfer Genes Into the Central Nervous System for Treatment of Neurodegenerative Disorders. Adenovirus-Mediated Gene Therapy of Tumours in the Central Nervous System. Gene Delivery Using Adeno-Associated Virus. Herpes Simplex Virus-Based Vectors. Gene Delivery Using HSV-1 Plasmid Vectors. Problems in the Use of Herpes Simplex Virus as a Vectors. Gene Delivery to the Nervous System By Direct Injection of Retroviral Vector. Gene Delivery to the Nervous System Using Retroviral Vectors. Transplantation of Genetically Modified Non-Neuronal Cells in the Central Nervous System. Genetic Animal Models for Alzheimer's Disease. Neuronal Precursors in the Brain of Adult Mammals: Biology and Applications. Direct Injection of Plasmid DNA Into the Brain. Antisense Oligodeoxynucleotides as Novel Neuropharmacological Tools for Selective Expression Blockade in the Brain.
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