Cell proliferation in cancer : regulatory mechanisms of neoplastic cell growth
著者
書誌事項
Cell proliferation in cancer : regulatory mechanisms of neoplastic cell growth
（Oxford medical publications）
Oxford University Press, 1996
- : hardback
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Research in cellular and molecular biology has reached the point now where it is possible to begin to see how the different fields of cancer genetics/oncogene research and intercellular communication form an integrated molecular model for the regulation of normal and neoplastic cell proliferation. A number of important discoveries in this field during the past few year shave greatly increased our understanding of cancer biology and have offered new diagnostic and
prognostic parameters in oncology. This information also holds the promise of novel, more effective therapeutic approaches to cancer. However, it is becoming increasingly difficult for an individual to maintain a wide and informed knowledge of current concepts in this rapidly moving field, or to form
an integrated overview of the myriad factors involved in neoplastic cell proliferation.
This book comprises a number of state-of-the-art reviews written by leading scientists. Each chapter gives a concise overview of specific intra-and intercellular events which regulate the proliferation of neoplastic cells, and the established and potential clinical implications of these developments. The topics have been selected to cover major recent advances in our understanding of the molecular events which govern cell division. It is expected that students, scientists and clinicians
working in the fields of oncology, pathology, and molecular/cellular biology would find this volume invaluable as a stimulating source of information.
目次
- Introduction: Cell proliferation and carcinogenesis
- 1. The cell cycle
- 2. Oncogenes and tumour-suppressor genes
- 3. Oncogenes and tumour-suppressor genes as prognostic indicators in the development of human tumours
- 4. The role of cytokines in tumour progression
- 5. Abnormal growth factor networks in neoplasia
- 6. The fibroblast growth factor family: Multifunctional regulators of cell proliferation
- 7. The potential and limitations of cytokine/growth factor manipulation in cancer therapy
- 8. Neuropeptides
- 9. Hormonal regulation of cancer cell growth
- 10. Retinoids in neoplasia
- 11. Metastasis: Secondary proliferation in distant organs
- 12. Apoptosis: a role in neoplasia?
- 13. Cell proliferation and its role in carcinogenesis and therapy
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