Delivery strategies for antisense oligonucleotide therapeutics

著者

• Akhtar, Saghir

書誌事項

Delivery strategies for antisense oligonucleotide therapeutics

edited by Saghir Akhtar

CRC Press, c1995

注記

Includes bibliographical references and index

内容説明・目次

内容説明

With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake, manipulating subcellular distribution and producing liposomal delivery systems for antisense agents are comprehensively covered in this volume. This book links review-type articles with contributions that contain exciting never-before-published data on the cellular delivery of oligonucleotides. It stimulates reading for both established researchers and newcomers to the antisense field.

目次

Preface Overview of Antisense Oligonucleotide Therapeutics and Delivery Disrupting the Flow of Genetic Information with Antisense Oligodeoxynucleotides: Research and Therapeutic Applications, D. Kregenow, M.Z. Ratajczak, and A. Gewirtz Cellular Delivery of Ribozymes, D.A. Elkins and J.J. Rossi Improved Structural Design and Cellular Uptake of GT-Rich Triplex-Forming Oligonucleotides, N. Choudhary, J.S. Bishop, K. Jayaraman, and J.K. Guy-Caffey Pharmacokinetic and Distribution Studies Pharmacokinetics and Delivery of Oligonucleotides to the Brain, L. Neckers, D.A. Geselowitz, and C. Chavany In Vivo Pharmacokinetics of Oligonucleotides Following Administration by Different Routes, V.V. Vlassov, L.A. Yakubov, V. Karamyshev, L. Pautova, E. Rykova, and M. Nechaeva Improving Biological Stability of Oligonucleotides Nuclease-Resistant Nucleic Acid Therapeutics, E. Wickstrom Self-Stabilized Oligonucleotides as Novel Antisense Agents, S. Agrawal, J. Temsamani, and J. Tang Circular Oligonucleotides as Potential Modulators of Gene Expression, E.T. Kool Peptide Nucleic Acids as Antisense Therapeutic Agents, J.C. Hanvey and L.E. Babiss Stabilized RNA Analogues for Antisense and Ribozyme Applications, H. Arup, O. Heindenreich, F. Eckstein Improving Membrane Transport and Targeted Delivery of Antisense Oligonucleotides Uptake and Localization of Phosphodeister and Chimeric Oligodeoxynucleotides in Normal and Leukaemic Primary Cells, A. Kreig Oligonucleotide Transport across Membranes and into Cells: Effects of Chemical Modifications, J. Hughes, A. Avroutskaya, H.M. Sasmoor, C.J. Guinosso, P.D. Cook, and R.L. Juliano Liposomes as a Delivery System for Antisense and Ribozyme Compounds, A. Thierry and G.B. Takle Intracellular Delivery of Oligonucleotides with Cationic Liposomes, C.F. Bennett The Delivery of Oligonucleotides Using pH-Sensitive Liposomes, C. Ropert, P. Couvreur, and C. Malvy Enhancing Endsosomal Exit of Nucleic Acids Using pH-Sensitive Viral Fusion Peptides, B. Oberhauser, C. Plank , and E. Wagner Targeted Delivery of Anti-Hepatitis B Antisense Oligonucleotides, E.P. Carmichael, H.C. Chiou, M.A. Findeis, G.L. Spitalny, and J.R. Merwin Design, Synthesis, and Cellular Delivery of Antibody Antisense Oligonucleotide Conjugates for Cancer Therapy, C.S.R. Gooden and A.A. Epenetos

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詳細情報

• NII書誌ID(NCID): BA26961311
• ISBN:
  • 0849347785
• LCCN: 94037132
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Boca Raton ; Tokyo
• ページ数/冊数: 305 p.
• 大きさ: 25 cm
• 分類:
  • LCC : RM666.A564
  • DC20 : 615/.31
• 件名:
  • LCSH : Antisense nucleic acids -- Therapeutic use
  • LCSH : Oligonucleotides -- Therapeutic use
  • LCSH : Drugs -- Dosage forms