Sterile dosage forms : their preparation and clinical application
著者
書誌事項
Sterile dosage forms : their preparation and clinical application
Lea & Febiger, 1994
4th. ed
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This fourth edition narrows the gap between those who manufacture and those who routinely prepare, dispense and administer parenteral drugs, by giving each group an appreciation of what the other must accoimplish to achieve the best in patient care. It covers all aspects of parenterals, including preparation, equipment and packaging. Intravenous Immune Globulins (IVIG) has broad biologic immune activity and is used for many diseases, including HIV infection. This work contains information on IVIG in the blood and blood products. There is also information about new developments in containers - they are now more environmentally friendly and have greater ease of disposability. The inclusion of a section on patient controlled analgesia (PCA) acknowledges that this type of administration is being used. There are also four new appendices. Appendices one and two detail understanding fluid dynamics when choosing an IV system and implantable and external central catheters. Appendices five and six cover parenterals derived from biotechnology and buyer's guides for pumps, controllers and IV devices.
目次
- Part 1: history of parenteral medication
- development of parenteral packaging
- development of routes of administration
- advantages of parenteral administration
- disadvantages of parenteral adminstration. Part 2: composition
- types of preparations
- vehicles
- added substances for parenterals
- added substances for sterile suspensions
- added substances for ophthalmic solutions. Part 3 characteristics
- sterility
- freedom from particulate matters
- freedom from pyrogens
- stability. Part 4: large scale preparation
- environmental control
- personnel
- packaging components
- preparation for packaging components
- preparation on product
- control
- labelling. Part 5: extemporaneous preparation
- parenteral manufacturing in hospitals
- environmental control
- personnel
- packaging components
- injections
- subdivision of solution
- sterile solids
- sterile suspensions
- quality control. Part 6: handling and administration, Faye Consentino
- the patient
- personnel administering parenteral drugs
- techniques of parenteral adminstration
- intermittent intravenous therapy
- initiating and maintaining an intravenous system
- complications of intravenous therapy. Part 7: biopharmaceutic factors influencing drug availability
- physicochemical influences on bioavailability
- physiologic factors influencing drug absorption
- dosage form considerations
- drug absorption and bioavailability from intramuscular injection
- drug absorption from subcutaneous injection
- biopharmaceutics of intrathecal injections
- parenteral administration of peptides and proteins
- parenteral drug delivery systems. Part 8: large-volume sterile solutions
- large-volume solutions for intravenous use
- large-volume solutions not administered intravenously
- intravenous fluid administration systems
- storage of intravenous fluids
- methods of intravenous administration
- flow rates of intravenous infusion fluids
- flow control in I.V. therapy
- selection of infusion devices
- justification for infusion devices
- committee for instrument selection
- criteria for using infusion devices
- standardized concentration for drugs administered by constant infusion
- mechanical controlling devices
- recommendations for infusion devices
- patient-controlled analgesia (PCA)
- future trends for infusion devices
- plastic medical components
- I.V. terms
- national co-ordinating committee on large volume parenterals
- trends and developments in I.V. delivery systems
- large-volume parenterals (LVPs) with manufactured additives (premixes)
- mini-infuser pumps for intermittent I.V. drug delivery. (Part contents).
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