Nasal toxicity and dosimetry of inhaled xenobiotics : implications for human health

Author(s)

Bibliographic Information

Nasal toxicity and dosimetry of inhaled xenobiotics : implications for human health

cosponsors, Chemical Industry Institute of Toxicology ... [et al.] ; organizing committee, chairman, F. Miller ... [et al.]

Taylor & Francis, c1995

Uniform Title

Inhalation toxicology. V. 6 (Supplement)

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Note

"Published simultaneously as a special issue of Inhalation toxicology."

Includes bibliographical references and index

Description and Table of Contents

Description

The location and severity of toxic responses in the noses of laboratory animals following inhalation of various compounds is attracting a growing number of researchers. This interest has arisen not only due to types of responses observed, but also because of the increased use of animal toxicological data for assessing human health risks from exposure to these compounds. This work addresses nasal dosimetry and toxicity of Inhaled Xenobiotics.; Originally Published As A Special Issue Of The journal "Inhalation Toxicology", the contributions are derived from a Chemical Industry Institute of Toxicology CIIT symposium held in September 1993 in Durham, North Carolina. The overview articles, covering topics like end points and responses of concern in humans, enable the reader to integrate information contained in later articles which treat the overview subjects in greater depth.; Next, mathematical and physical models that can be used to study the deposition of inhaled compounds in the upper respiratory tracts of humans and animals are considered. Approaches for experimental dosimetry studies and a number of dosimetry case studies are presented. The third series of articles examine chemically induced nasal responses in animals and humans. Integrating all the previous information, the final section discusses the use of nasal dosimetry and toxicity data for assessing human health implications and establishing appropriate exposure limits.

Table of Contents

  • Our Upper Airways and Our Ambient Air: A Historical Perspective
  • Research Strategy for Assessing Human Risk from Inhaled Nasal Toxicants
  • Nasal Toxicity: End Points of Concern in Humans
  • Nasal Dosimetry, Lesion Distribution and the Toxicologic Pathologist: A Brief Review
  • Nasal Dosimetry in Animals and Man: Mathematical and Physical Models
  • Measurements of Uptake
  • Modelling the Uptake of Gases by the Dog Nasal- Pharyngeal Region: Effects of Morphometric and Physiochemical Factors
  • Chemically Induced Nasal Response in Humans and Rodents
  • Spectrum of Responses Seen in Humans: Human Olfactory Epithelium: Normal Patterns and Types of Lesions Found in the General Population
  • Implications for Human Health and Exposure Limits
  • Management of Occupational Exposure Levels in the United States
  • Evaluation of the Nasal Tract Lesions in Derivation of the Inhalation Reference Concentration for Hexamethylene Diisocyanate.

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