Immune tolerance and the treatment of hemophiliacs with an inhibitor : proceedings of the Workshop on Immune Tolerance, Rome, August 21-23, 1994
著者
書誌事項
Immune tolerance and the treatment of hemophiliacs with an inhibitor : proceedings of the Workshop on Immune Tolerance, Rome, August 21-23, 1994
（Vox sanguinis, v. 70 ; Supplement ; 1）
S. Karger, 1996
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注記
Includes bibliographical references
内容説明・目次
内容説明
A major complication preventing adequate treatment of hemophilia patients is the development of inhibitory antibodies against factor VIII. In this case, one of the best therapeutic approaches currently available is the induction of immune tolerance, a method first described in 1976. Immune tolerance can be restored in most hemophiliacs who have developed an inhibitor through the administration of high doses of factor VIII, making it possible to treat bleeding episodes with normal quantities of factor VIII, to increase the patient's survival chances and to reduce the cost of further treatment. Presenting the proceedings of an international workshop, this publication reviews the epidemiology and pathophysiology of FVIII inhibitors, and the mechanisms leading to immune tolerance. Covering the various treatment protocols applied worldwide, clinical issues as well as economic and organizational aspects, it provides essential information for doctors treating hemophiliacs and all those working in the fields of hematology, immunology, pharmacology, pediatrics and blood transfusion.
目次
- Epidemiology of inhibitors in haemophilia A, W. Kreuz et al
- human anti-factor VIII antibodies - epitope localization and inhibitory function, D. Scandella
- variations in antigenicity of factor VIII concentrates - preclinical evaluation, J.M. Saint-Remy and J.G. Gilles
- the treatment of factor VIII inhibitors - a general overview, G.C. White and H.R. Roberts
- delineating physiological (natural) autoreactivity from pathological autoimmunity, M.D. Kazatchkine
- immune tolerance for the treatment of factor VIII inhibitors - 20 years "Bonn protocol", H.H. Brackmann et al
- immune tolerance and the immune modulation protocol, E. Berntorp and I.M. Nilsson
- the international registry of immune tolerance - 1994 update, A. Ghirardini et al
- induction of immune tolerance, the future of the registry, N.P. Ewing
- immunological and laboratory aspects of immune tolerance, M. Kazatchkine and L. Hoyer
- protocols, dosages and clinical aspects of immune tolerance, J. Lusher and M. Mariani
- low-dose immune tolerance therapy - the Van Creveld model, E.P. Mauser-Bunschoten et al
- induction of tolerance using porcine factor VIII, C.R.M. Hay and Y. Laurian
- immune tolerance - a nursing perspective, R.B. Butler
- immune tolerance in two high responder, severe haemophilia A patients with inhibitors - the importance of high doses and the duration of the treatment, N. Ciavarella et al
- economic and organizational considerations of immune tolerance, C.M. Kessler and L.M. Aledort
- inhibitors to coagulation - can we afford immune tolerance induction regimens?, L.M. Aledort.
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