Therapeutic peptides and proteins : formulation, processing, and delivery systems

著者

• Banga, Ajay K.

書誌事項

Therapeutic peptides and proteins : formulation, processing, and delivery systems

Ajay K. Banga

Technomic Pub., c1995

注記

Includes bibliographical references and index

内容説明・目次

内容説明

From the Preface At the time of this writing, the American biotechnology and pharmaceutical industry has more than two dozen biotechnology-derived therapeutic proteins on the market, while several hundred are in various stages of human clinical trials or at the FDA for review. Today, more than a thousand companies are involved in biotechnology research, with a total revenue of $7.7 billion for 1993. Therapeutic peptides and proteins are expected to mitigate suffering in coming years as anticancer agents, hormones, growth factors, analgesics, anti-hypertensives, and thrombolytics, among others. However, the clinical application of these therapeutic peptides and proteins is limited by several problems, such as lack of physical and chemical stability or the lack of desirable attributes for adequate absorption or distribution. Thus, as these therapeutic peptides and proteins are made available, it will be essential to formulate these drugs into safe, stable and efficacious delivery systems. The pharmaceutical scientist involved in this effort needs to call upon the knowledge of several disciplines, such as pharmaceutics, medicinal chemistry, biochemistry, and microbiology, and needs to keep abreast with the latest research in the published literature. This book presents these principles in a simple, interesting and practically useful manner for the benefit of scientists working in this area and to further research in this area. This book will also provide useful information for students and academic researchers and add to their interest in this area. The book should also be useful in a hospital setting to understand potential physicochemical stability problems that may result during reconstitution or administration of the new recombinant proteins. Since this field is relatively new and rapidly evolving, efforts were made to include very recent literature in the book. As a result, over 40% of the literature citations in the book are for the work published in the last two years.

目次

Preface Part I: Formulation and Processing Pharmaceutical Biotechnology: The Arrival of Recombinant Proteins Introduction - What is Biotechnology? - The Biotechnology Industry - Regulatory Aspects of Biotechnology-Derived Drugs - Structure-Based Drug Design - Conclusions - References Structure and Analysis of Therapeutic Peptides and Proteins Introduction - Amino Acids: Building Blocks of Proteins - Structure of Peptides and Proteins - Protein Conformation and Other Structural Features - Analytical Methods - Conclusions - References Stability of Therapeutic Peptides and Proteins Introduction - Physical Instability - Chemical Instability - Conclusions - References Formulation of Therapeutic Peptides and Proteins Introduction - Formulation Development - Pharmaceutical Excipients in Formulations - Aggregation in Protein Formulations - Novel Formulation Approaches - Accelerated Stability Testing - Conclusions - References Pharmaceutical Processing and Handling of Therapeutic Peptides and Proteins Introduction - Protein Destabilization Induced by Pharmaceutical Processing - Lyophilization as a Pharmaceutical Process - Alternate Pharmaceutical Processes - Handling of Therapeutic Peptides and Proteins - Conclusions - References Part II: Drug Delivery Systems Pharmacokinetics of Peptide and Protein Drugs Introduction - Pharmacokinetic Parameters - Examples of Protein Pharmacokinetics - Other Pharmacokinetic/Pharmacodynamics Considerations - Transport of Peptides Across the Blood-Brain Barrier - Conclusions - References Parenteral Controlled Delivery of Therapeutic Peptides and Proteins Introduction - Polymers Used for Controlled Delivery of Peptides and Proteins - Parenteral Controlled Release Systems - Conclusions - References Oral Delivery of Peptide and Protein Drugs Introduction - Barriers to Protein Absorption and Pathways of Penetration - Approaches to Improve Oral Delivery - Methods to Study Oral Absorption - Oral Immunization - Conclusions - References Transdermal and Topical Delivery of Therapeutic Peptides and Proteins Introduction - Approaches to Enhance Transdermal Peptide Delivery - Iontophoresis - Topical Delivery of Therapeutic Peptides and Proteins - Conclusions - References Mucosal Delivery of Therapeutic Peptides and Proteins Introduction - Nasal Delivery - Pulmonary Delivery - Rectal Delivery - Buccal Delivery - Ocular Delivery - Comparative Evaluation of Mucosal Routes - Conclusions - References Index

「Nielsen BookData」 より

詳細情報

• NII書誌ID(NCID): BA27219556
• ISBN:
  • 1566763290
• LCCN: 95061206
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Lancaster, Pa.
• ページ数/冊数: xiii, 317 p.
• 大きさ: 24 cm