The somatotrophic axis and the reproductive process in health and disease
著者
書誌事項
The somatotrophic axis and the reproductive process in health and disease
Springer-Verlag, c1995
- : us : acid-free paper
大学図書館所蔵 全2件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
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  フランス
  ベルギー
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注記
"Proceedings of the Symposium on the Somatotrophic Axis and the Reproductive Process in Health and Disease, sponsored by Serono Symposia, USA, Inc., held October 28 to 31, 1993, in Baltimore, Maryland"--T.p. verso
Includes bibliographical references and indexes
内容説明・目次
内容説明
For many years now, our understanding of the somatotrophic and reproduc tive axes has evolved essentially independently, both fields of study reaching a highly advanced, although far from complete, level of under standing. Along the way, however, it became apparent that in some circumstances the reproductive and somatotrophic axes may be inter dependent. Inklings to this effect were at times feeble and at other times more convincing. Among those inklings are the clinical recognition by pediatric endocrinologists of the apparent association between isolated GH deficiency and delayed puberty, as well as of the apparent permissive, pUberty-promoting property of GH. Equally important is a body of experi mental studies establishing the ovary of multiple species as a site of GH reception and action. Arguing against an essential role for GH in the reproductive process is the observation that individuals who have GH resistance of the Laron variety are fertile arid that isolated GH deficiency does not constitute an absolute barrier to the attainment of sexual maturation and fertility. The intraovarian insulin-like growth factor (IGF) hypothesis proposes that IGFs may serve as amplifiers of gonadotropin action. Although the dependence of intraovarian IGFs on systemic GH action has never been unequivocally demonstrated, that leap of faith has often been made. The intraovarian IGF hypothesis serves as the rationale for the adjunctive use of GH in the induction of ovulation.
目次
I. Growth Hormone and Its Receptor: State of the Art.- 1. Growth Hormone: A Current Perspective.- 2. Probing and Designing Growth Hormone-Receptor Interactions.- 3. Human Growth Hormone Binding Proteins: Regulation and Physiological Significance.- 4. Ovarian Prolactin Receptors and Their Placental Ligands.- 5. Regulatory Actions of Testosterone on Pulsatile Growth Hormone Secretion in the Human: Studies Using Deconvolution Analysis.- 6. Growth Hormone and IGF-I as Anabolic Partitioning Hormones.- II. Pubertal, Menstrual, Gestational, and Menopausal Adaptation.- 7. Growth Hormone Secretory Dynamics During Puberty.- 8. Impact of Growth Hormone on the Timing and Progression of Puberty: How Are Growth and Sexual Maturation Linked?.- 9. Role of Growth Hormone in the Promotion of Linear Skeletal Growth.- 10. Growth Hormone Economy in Normally Cycling Women.- 11. Gestational Physiology of the Growth Hormone Gene Family.- 12. Growth Hormone Economy in Menopausal Women: Effects of Age.- 13. Growth Hormone Economy in Hypogonadism: Effects of Sex Steroids.- III. Growth Hormone: The Ovarian Connection.- 14. Ovary as a Site of Growth Hormone Reception and Action.- 15. Ovarian IGF System: Interface with the Gonadotropic and Somatotrophic Axes.- 16. Is the Intraovarian IGF System a Mediator of Growth Hormone Action?.- 17. Evidence for a Role of Growth Hormone-Insulin-Like Growth Factor System in the Polycystic Ovary Syndrome (PCOS).- 18. Evidence Against a Role for the Growth Hormone-Insulin-Like Growth Factor System in the Polycystic Ovary Syndrome.- IV. Potential Utility of Growth Hormone in Clinical Reproductive Medicine.- 19. Diagnosing Growth Hormone Deficiency in Adults.- 20. Growth Hormone Delivery, Dosing, and Pharmacokinetics in Adults.- 21. Role of Growth Hormone Therapy inTurner Syndrome.- 22. Role of Growth Hormone in the Treatment of Postmenopausal Osteoporosis.- V. Potential Utility of Growth Hormone in Ovulation Induction.- 23. Evidence for the Utility of Growth Hormone in the Enhancement of Ovulation.- 24. Evidence Against the Utility of Growth Hormone in the Enhancement of Ovulation.- Author Index.
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