Therapeutic modulation of cytokines

著者

書誌事項

Therapeutic modulation of cytokines

edited by Brian Henderson, Mark W. Bodmer

（Pharmacology & toxicology）

CRC Press, c1996

大学図書館所蔵 件 / 全8件

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Cytokines are peptide or protein cell-to-cell signaling molecules that play vital roles in normal cell and tissue homeostasis, as well as in responses to infectious agents. Because of their importance in virtually all forms of pathology, the pharmaceutical industry is devoting great effort to develop methods for the control of cytokine synthesis or action. This is the first volume to bring together experts from academia and the pharmaceutical industry to discuss problems and solutions in the therapeutic control of cytokines. An introductory section reviews the biology, physiology, and pathology of cytokines. Internationally recognized scientists then discuss the development of low molecular mass inhibitors, including inhibitors of cytokine convertases and oligonucleotide drugs. The potential use of natural inhibitors such as soluble receptors, interleukin-1 receptor antagonists, and anti-cytokine antibodies is detailed. This interesting book also covers intracellular signaling pathways induced by pro-inflammatory cytokines and the bio-modulatory activity of specific cytokines such as TGF-ss. Therapeutic Modulation of Cytokines will interest academic scientists in biochemistry, cell biology, pharmacology, and molecular biology and biological scientists in the pharmaceutical and biopharmaceutical industries.

目次

Cytokine Physiology and Pathophysiology Cytokine Physiology, A. Meager Immunoregulatory Cytokines, F.S. diGiovine, J.B. Mee, and G.W. Duff Cytokines in Inflammation: An Overview, E.R. Pettipher Overview of Cytokine Modulation, B. Henderson Low Molecular Mass Cytokine Inhibitors Low Molecular Weight Inhibitors of Cytokine Synthesis, A.R. McKenzie Immunosuppressants as Cytokine Inhibitors, J.A. Schmidt and R.V. Bundick Cytokine Convertase Inhibitors, D.K. Miller Oligonucleotide-Based Inhibitors of Cytokine Expression and Function, C.F. Bennett and S.T. Crooke Naturally Occurring Inhibitors and Neutralizing Antibodies Interleukin-1 Receptor Antagonist, S.M. Opal TNFa Neutralization by Biological Antagonists, M.W. Bodmer and R. Foulkes Anti-Interleukin-5 Antibodies as Therapeutic Agents in Asthma and Other Eosinophilic Diseases, R.W. Egan, F.M. Cuss, S.P. Umland, and R.W. Chapman Modulation of Cytokine Signal Transduction Signal Transduction Mechanisms of Interleukin-1 and Tumor Necrosis Factor, J. Saklatvala Modulatory Cytokines Transforming Growth Factor-Betas: Endogenous Immunosuppressive and Anti-Inflammatory Molecules, G.M. Hochwald, M.A. Palladino, and G.J. Thorbecke Interleukin-10, J. Banchereau, F. Briere, C. Caux, A.-C. Fluckiger, P. Merville, and F. Rousset

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