Therapeutic modulation of cytokines
著者
書誌事項
Therapeutic modulation of cytokines
（Pharmacology & toxicology）
CRC Press, c1996
大学図書館所蔵 全8件
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Cytokines are peptide or protein cell-to-cell signaling molecules that play vital roles in normal cell and tissue homeostasis, as well as in responses to infectious agents. Because of their importance in virtually all forms of pathology, the pharmaceutical industry is devoting great effort to develop methods for the control of cytokine synthesis or action.
This is the first volume to bring together experts from academia and the pharmaceutical industry to discuss problems and solutions in the therapeutic control of cytokines. An introductory section reviews the biology, physiology, and pathology of cytokines. Internationally recognized scientists then discuss the development of low molecular mass inhibitors, including inhibitors of cytokine convertases and oligonucleotide drugs. The potential use of natural inhibitors such as soluble receptors, interleukin-1 receptor antagonists, and anti-cytokine antibodies is detailed. This interesting book also covers intracellular signaling pathways induced by pro-inflammatory cytokines and the bio-modulatory activity of specific cytokines such as TGF-ss. Therapeutic Modulation of Cytokines will interest academic scientists in biochemistry, cell biology, pharmacology, and molecular biology and biological scientists in the pharmaceutical and biopharmaceutical industries.
目次
Cytokine Physiology and Pathophysiology
Cytokine Physiology, A. Meager
Immunoregulatory Cytokines, F.S. diGiovine, J.B. Mee, and G.W. Duff
Cytokines in Inflammation: An Overview, E.R. Pettipher
Overview of Cytokine Modulation, B. Henderson
Low Molecular Mass Cytokine Inhibitors
Low Molecular Weight Inhibitors of Cytokine Synthesis, A.R. McKenzie
Immunosuppressants as Cytokine Inhibitors, J.A. Schmidt and R.V. Bundick
Cytokine Convertase Inhibitors, D.K. Miller
Oligonucleotide-Based Inhibitors of Cytokine Expression and Function, C.F. Bennett and S.T. Crooke
Naturally Occurring Inhibitors and Neutralizing Antibodies
Interleukin-1 Receptor Antagonist, S.M. Opal
TNFa Neutralization by Biological Antagonists, M.W. Bodmer and R. Foulkes
Anti-Interleukin-5 Antibodies as Therapeutic Agents in Asthma and Other Eosinophilic Diseases, R.W. Egan, F.M. Cuss, S.P. Umland, and R.W. Chapman
Modulation of Cytokine Signal Transduction
Signal Transduction Mechanisms of Interleukin-1 and Tumor Necrosis Factor, J. Saklatvala
Modulatory Cytokines
Transforming Growth Factor-Betas: Endogenous Immunosuppressive and Anti-Inflammatory Molecules, G.M. Hochwald, M.A. Palladino, and G.J. Thorbecke
Interleukin-10, J. Banchereau, F. Briere, C. Caux, A.-C. Fluckiger, P. Merville, and F. Rousset
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