Regulation of cardiac function : molecular, cellular and pathophysiological aspects
著者
書誌事項
Regulation of cardiac function : molecular, cellular and pathophysiological aspects
Japan Scientific Societies Press , VNU Science Press BV, 1984
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注記
Includes references
内容説明・目次
内容説明
This book gives a consensus of views and research trends in the regulation of cardiac function and metabolism. Emphasis is given to the elucidation of fundamental concepts and principles of clinically relevant issues. The aim is that the clinician should be able to approach a particular aspect of any given problem logically, thereby gaining insights into the fundamental pathophysiological mechanism underlying diseases states.
Regulation of Cardiac Function is organized within six principle areas from the molecular and cellular aspects to more clinically applied problems of heart disease. This book gives pertinent guidelines and summarizes knowledge on basic research relevant to cardiac function and metabolism in health and disease.
目次
Preface
Introduction
CHAPTER 1: CARDIAC CONTRACTILE PROTEINS AND EXCITATION CONTRACTION COUPLING
Excitation-contraction coupling and Ca2+
Arnold M. Katz
Involvement of the sarcolemmal membrane in cardiac contraction and relaxation
N.S. Dhalla
Ionic mechanisms and their regulation in cardiac excitation
M. Hiraoka
Control of Ca ion by the cardiac sarcoplasmic reticulum
M. Endo
Contractile mechanisms of heart muscle
I. Matsubara
Regulation of cardiac function cardiac myosin isozymes: a molecular and cellular study
Y. Yazaki
CHAPTER 2: ULTRASTRUCTURE OF THE MYOCARDIUM
Ultrastructure and function of the myocardium
V.J. Ferrans
Architecture of hypertrophied myocardium: scanning and transmission electron microscopy
K. Kawamura
Myocardial ultrastructure in cardiomyopathic animals
H. Tanaka
Histology of the human conduction system
R. Okada
CHAPTER 3: ISCHEMIC HEART AND ENERGY METABOLISM
Role of metabolism on ischaemia
L.H. Opie
Energy metabolism in ischemic myocardium: NMR study
S. Imai
Cardiac oxygen metabolism
M. Tamura
The role of phospholipase in mitochondrial dysfunction after coronary reperfusion
T. Ozawa
Role of L-carnitine in ischemic heart disease
N. Yamazaki
CHAPTER 4: PUMP FUNCTION IN NORMAL AND FAILING HEART
Heterogeneous transmural blood flow and microvascular spasm as causes of heart failure in ischemic heart disease and cardiomyopathies
E.H. Sonnenblick
Dynamic property of ventricular relaxation
M. Hori
Contractile state of the hypertrophied ventricle
S. Sasayama
Diastolic performances of ischemic left ventricle
M. Iizuka
CHAPTER 5: CORONARY VASOPLASM AND THROMBOSIS
Thrombosis, platelets and coronary atherosclerosis
K. Tanaka
Mechanism of vasospasm and thrombosis in coronary artery disease: altered metabolism of thromboxane A2 and prostaglandin I2
M. Tada
Prostaglandin and blood vessel function
N. Toda
Coronary artery spasm in experimental animals
M. Nakamura
CHAPTER 6: CARDIOVASCULAR PHARMACOLOGY
The cultured myocardial cell as a model in heart research
A. Wollenberger
The mechanism of beta-adrenergic stimulation of adenylate cyclase in the heart
P. Harris
Profiles of new positive inotropic drugs
N. Taira
Efficacies of antianginal drugs in relation to pathophysiology of angina pectoris
H. Fukuzaki
Functions of the specialized conducting system and their regulation
Y. Watanabe
Subject index
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