HDL deficiency and atherosclerosis
著者
書誌事項
HDL deficiency and atherosclerosis
（Developments in cardiovascular medicine, v. 174）
Kluwer Academic Publishers, c1995
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The discovery that plasma cholesterol and lipoprotein concentrations are major predictors of risk has been one of the most important factors behind the dramatic and steady reduction in deaths due to coronary heart disease seen over the last 30 years. However, although the significance of lipids is now well understood, we have yet to identify the ideal way to protect patients, particularly those with inherited lipoprotein disorders, against atherosclerosis. New work described in this book sheds light on that important issue, especially on the role of the A apoproteins in HDL. For example, experimental gene transfer studies indicating that apoprotein A-1 may counteract the hyperlipidaemia and atherosclerosis found in apo-E deficiency suggest that we may soon be able to offer prophylaxis to patients whose risk of heart disease is greatly increased by a genetically-determined shortage of HDL.
目次
- 1. Molecular genetics approach to lipoprotein metabolism disorders
- H. Funke, et al. 2. Role of high density lipoprotein subclasses in reverse cholesterol transport
- A. von Eckarstein, et al. 3. Connection between cholesterol efflux and atherosclerosis
- J.C. Fruchart, et al. 4. HDLc as a therapeutic target in coronary disease: current concepts and future directions
- B.G. Brown, et al. 5. Intracellular cholesterol transport
- U. Seedorf, et al. 6. Apolipoprotein E and Alzheimer's disease
- R.W. Mahley. 7. HDL metabolism and atherogenesis in genetically modified mice
- N. Maeda, et al. 8. Gene therapy for the genetic dyslipoproteinemias
- H.B. Brewer, et al.
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