Animal test alternatives : refinement, reduction, replacement

著者

書誌事項

Animal test alternatives : refinement, reduction, replacement

edited by Harry Salem

M. Dekker, c1995

  • : acid-free paper

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Examines a range of alternatives to the use of animals in research and testing, evaluating the latest developments in the field, indicating future directions and explaining the regulatory climate that surrounds the technologies presented. Ocular, dermal, hepatic, renal, respiratory, cardiovascular and environmental aspects of testing and research are addressed.

目次

  • The evolution of in vitro toxicology in the pharmaceutical industry
  • relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models
  • using theoretical descriptors in quantitative structure activity relationships
  • structure-activity predictions as alternatives to animal tests
  • the aquatic toxicology of isopropylamine - comparison of experimentally derived values with structure activity predictions
  • structure-activity relationships and the validation of in vitro toxicology tests
  • applications of liver and kidney cell systems that can reduce animal usage
  • in vitro methods for hepatotoxic assessment of halogenated fatty acids
  • tissue slices as an in vitro model for studying heart, liver, and kidney toxicity
  • potential for interspecies extrapolation of macrophage chemiluminescence data from immunotoxicology studies
  • an in vitro system for the evaluation of cyanide ion binding by potential candidate antidotes
  • munitions cytotoxicities in vitro
  • neuroblastoma-glioma cells as a system for studying drug neurotoxicity
  • in vitro assays for muscle irritation
  • general overview of in vitro and other alternatives to skin toxicity evaluation
  • in vitro dermal toxicity assays - validation with human data
  • skin penetration and allergic contact dermatitis - historical perspective
  • toward a predictive model for allergic contact dermatitis
  • a three-dimensional human skin model for toxicity testing
  • the SOLATEX-PI system - an in vitro method to predict photoirritation
  • feasibility of fluorescence assays in human skin equivalents with the cytofluor
  • ocular testing - historical perspectives
  • overview of in vitro ocular irritation test systems and other evaluation status
  • the role of in vitro tests in assessing the safety of cosmetics and consumer products
  • in vitro and other alternatives in inhalation toxicology - monitoring biologic markers of cellular and biochemical response. (Part Contents).

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