Advances in protein design, international workshop 1988
著者
書誌事項
Advances in protein design, international workshop 1988
（GBF monographs, v. 12）
VCH, c1989
- : gw
- : us
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注記
Includes bibliographical references
内容説明・目次
内容説明
A compilation which evolved from a workshop held at the GBF in 1988 laying special emphasis on the following topics: methods and theoretical concepts, protein design with (industrial) enzymes and protein design with biological response modifiers, including antibodies and protease inhibitors.
目次
- Part 1: Methods and theoretical concepts: thermodynamic and kinetic aspects of the folding and self-assembly of proteins
- folding of peptide fragments in water solution - implications for initiation of protein folding
- determination of protein structures by NMR - approaches towards extending the limits
- new developments in protein crystallography
- a computational tool for structural biology - crystallographic refinement by simulated annealing
- knowledge-based protein modelling and design
- computer aided protein design - methods and applications
- computer simulations applied to site specific mutagenesis and ligand binding - the use of free energy perturbation methods. Part 2 Protein design with (industrial) enzymes: three dimensional structure determination of proteins in PERI
- engineering of RNase T1
- tertiary structure of xylanase and estimation of active sites by site directed mutegenesis
- modification of milk-clotting aspartic proteases, chymosin and mucor rennin
- towards the construction of new proteins
- lacate dehydrogenase - effect of amino acid changes of properties
- protein engineering of human Lysozyme
- design and structures of disulfide containing subtilisin variants. Part 3 Protein design with biological response modifiers, including antibodies and protease inhibitors: design of novel insulins with changed self-association and ligand binding properties
- human glycoproteins and derived variants from recombinant mammalian cell lines
- the crossover linker - mechanisms and applications in gene modification
- structure-function relationship in parathyroid hormone
- structural and functional aspects of protein - protein interaction as studied through crystal structure of subtilisin complexed with its trapped substate SS1
- genetic engineering of protease inhibitors, a1-antitrypsin and hirudin
- design of efficient human leukocyte elastase inhibitors - variants of human pancreatic secretory trysin inhibitor
- characterization of engineered proteins - some critical reflections.
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