Receptor desensitization and Ca[2][+]-signaling : cellular aspects of possible molecular dynamics
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書誌事項
Receptor desensitization and Ca[2][+]-signaling : cellular aspects of possible molecular dynamics
Japan Scientific Societies Press , Karger, c1996
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内容説明・目次
内容説明
The last decade has witnessed a wealth of new information on the mechanisms underlying cell signaling. Molecular approaches have revealed the identity and structure of many of the receptor proteins which permit cells to respond to different chemical signals. An important mechanism regulating receptor function is desensitization, i.e. the suppression of a cellular response induced by the continuous presence of a constant agonist stimulus. This book features selected studies on receptor-mediated desensitization in various cells and tissues triggered by Ca2+. Post-receptor mechanisms are also considered. The contributions focus on muscarinic, histamine and adrenergic receptor systems as well as the phosphoinositidase C signaling pathway. The authoritative information compiled in this book will not only prove of great value to researchers interested in signal transduction but is also crucial for the development of new drugs.
目次
- Muscarinic receptor systems: Dual processes of desensitization and resensitization regulate cellular responsiveness in smooth muscle of guinea-pig taenia caeci, S. Hishinuma et al
- Threshold change in muscarinic receptor-operated all-or-none response by desensitization in isolated single smooth muscle cells from taenia caecum, M. Mita et al
- Diversity of desensitization of secretion in basophilic leukemia cells transfected with muscarinic receptor m2 and m3 sybtypes, K. Oishi, M.K. Uchida. Histamine receptor systems: Desensitization of cellular responses mediated by histame H1-receptor in central nervous system tissues, S. Hishinuma et al. Phosphoinositides/Ca2+ signaling systems: Regulation and desensitization of the phosphoinositidase C signaling pathway, A.B. Tobin et al.
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