Genetics and cancer susceptibility : implications for risk assessment : proceedings of the Eighth International Conference on Carcinogenesis and Risk Assessment, held in Austin, Texas, November 30-December 3, 1994

書誌事項

Genetics and cancer susceptibility : implications for risk assessment : proceedings of the Eighth International Conference on Carcinogenesis and Risk Assessment, held in Austin, Texas, November 30-December 3, 1994

editors, Cheryl Walker ... [et al.]

(Progress in clinical and biological research, v. 395)

Wiley-Liss, 1996

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Recent advances in molecular genetics have provided new information facilitating identification of human subpopulations at increased risk for cancer development. This volume reviews the impact of both intrinsic genetic factors and extrinsic modifiers on human cancer risk. Emphasis is on susceptibility factors that are targets for chemical carcinogens, on intrinsic factors that modify cancer risk and on biomonitoring and extrinsic risk modification.

目次

  • Genetic Basis of Human Cancer Susceptibility
  • Identification of BRCA1 - Implications for Risk Assessment
  • Tumor Suppressor Genes
  • A Model for Development of Human Breast Cancer - The Role of Human Activated pp60c-src in Mammary Carcinogenesis in Transgenic Mice
  • Effects of p53 Loss on Genetic Instability and Tumor Progression in a Mouse Mammary Cancer Model
  • Genetic Dissection of Tumor Susceptibility - The Mouse Model and Human Implications
  • Genetic Susceptibility to In Vivo and In Vitro Cell Transformation
  • A Novel Genetic Locus (TLS1) That Regulates N-Methy-N-Nitrosourca Induced Thymic Lymphoma Development in Mice
  • Genetic Control of Murine Hepatocarcinogenesis
  • Genetic Susceptibility to Tumor Progression
  • One Decade of Comparative Molecular Carcinogenesis
  • Validation Issues for the Use of Transgenic Mouse Mutation Assays in Risk Assessment
  • The Validation of Susceptibility Biomarkers in Epidemiologic Studies
  • Legal and Ethical Issues in Screening for Genetic Susceptibility
  • Metabolic Phenotypes and Carcinogen-DNA Adducts in Humans
  • Genetic Polymorphisms and Increased Cancer Risk
  • Endogenous DNA Damage and Its Repair
  • Epidemiology of Susceptibility to Breast Cancer
  • DNA Repair and the Epidemiology of Basal Cell Carcinoma
  • The Role of DNA Repair in Mutagenesis and Carcinogenesis
  • Human Health Risk Assessment Research Needs
  • Future Directions for Risk Assessment - From Host Factors to Genetic Susceptibility
  • Carcinogen-Derived Biomarkers and Tobacco Related Cancer
  • Aflotoxin and Hepatitis B Virus as Risk Factors for Hepatocellular Carinoma
  • Diet Inventervention for Modifying Cancer Risk.

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