Oncogenesis and molecular biology of pituitary tumors

著者

書誌事項

Oncogenesis and molecular biology of pituitary tumors

volume editor, Shlomo Melmed

（Frontiers of hormone research, vol. 20）

Karger, c1996

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

This comprehensive volume focuses on mechanisms leading to pituitary tumor formation and progression. The individual chapters provide timely updates on developments in the rapidly expanding field of pituitary tumor pathogenesis. Researchers from leading centers describe the fundamental functional anatomy of the pituitary, the structure and function of the hypothalamic hormone receptors as they relate to human pituitary adenomas, as well as disordered transcription factors, growth factors and signaling proteins in pituitary tumorigenesis. They also present transgenic models of pituitary tumor formation and report on chromosomal deletions observed in both hereditary and sporadic adenomas. The book is an essential and timely resource for basic and clinical endocrinologists, neurosurgeons and neuro-oncologists as it provides a state-of-the-art summary of our current understanding of the pathogenesis of these common tumors.

目次

  • Functional microanatomy of the hypophysial-pituitary axis, R.M. Lechan
  • pit-1 in pituitary tumors, I. Pellegrini and P. Jaquet
  • experimental and clinical models of CRH-induced pituitary tumors, M. Karl and G.P. Chrousos
  • experimental and clinical models of GHRH-induced pituitary tumors, L.A. Frohman
  • role of GnRH receptors in the pathogenesis of pituitary tumors, J.M. Alexander and A. Klibanski
  • somatostatin receptor subtypes in pituitary tumors, Y. Greenman and S. Melmed
  • g-protein dysfunction in pituitary tumors, A. Spada and G. Faglia
  • oncogenes and tumor suppressor genes in pituitary tumorigenesis, L. Pei and S. Melmed
  • role of parathyroid hormone-related peptide in the pathogenesis of pituitary adenomas, S. Yamashita et al
  • role of TGFalpha in pituitary tumorigenesis, J. McAndrew and J.E. Kudlow
  • role of chromosome 11 in hereditary and sporadic pituitary tumorigenesis, R.V. Thakker.

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