Metastasis-related molecules
著者
書誌事項
Metastasis-related molecules
(Current topics in microbiology and immunology, 213/1 . Attempts to understand metastasis formation ; 1)
Springer, c1996
大学図書館所蔵 全12件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
In metastasis, tumor cells disseminate from the primary lesion and home to secondary organs where they may remain dormant for a long time. Metastasis formation is still the most feared manifestation for tumor patients and clinicians. Although improvements have been made concerning earlier detection and specific therapy, most of the cancer patients still die of distant metastases. The pu-rpose of these three volumes is to review the recent progress in molecular metas- tasis research and to attempt to further understand the biol- ogy of this multifocal process. With respect to present day molecular biology, the pioneers of metastasis research established the basic concepts of metasta- sis formation in the 1970s and 1980s, namely, clonal selection of metastatic cells, heterogeneity of metastatic subpopulations, organ specificity of metastasis and the importance of angio- genesis (Fidler, Kripke, Nicolson, Folkman and others). In the 1980s and 1990s, several of the molecules involved were identified and their network interactions elucidated.
These three volumes of Current Topics in Microbiology and Immuno- logy compile the most recent developments on these meta- stasis-related molecules; their interactions, regulation, and ways to interfere with their action. It became evident that metastasis-related molecules are confined to distinct cellular compartments, such as the extracellular space, the cell membrane, the cytoplasmic signalling network, and the nuclear regulatory system. For the complex metastatic cascade, proteolysis and alterations in adhesive functions are the most obvious and thus one of the most thoroughly investigated processes.
目次
List of Contents.- Complex Roles of Matrix Metalloproteinases in Tumor Progression.- Membrane Type-Matrix Metalloproteinase and Tumor Invasion.- Plasminogen Activators and Angiogenesis.- Maspin: A Tumor Supressing Serpin.- Different Roles for Plasminogen Activators and Metalloproteinases in Melanoma Metastasis.- SPARC and the Extracellular Matrix: Implications for Cancer and Wound Repair.- MUC18: A Cell Adhesion Molecule with a Potential Role in Tumor Growth and Tumor Cell Dissemination.- Lu-ECAM-1 and DPP IV in Lung Metastasis.- The E-cadherin/Catenin Complex in Invasion and Metastasis.- Biological Characteristics of Micrometastatic Carcinoma Cells in Bone Marrow.- Model Systems of Carcinoma Cell Dispersion.- Involvement of ?6 and ?v Integrins in Metastasis.- The 67-kDa Laminin Receptor and Tumor Progression.- Joint Features of Metastasis Formation and Lymphocyte Maturation and Activation.- The CD44 Proteins in Embryonic Development and in Cancer.- CD44 in Malignant Disorders.
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