Signal transduction through growth factor receptors
著者
書誌事項
Signal transduction through growth factor receptors
(Advances in cell and molecular biology of membranes and organelles / series editor, Alan M. Tartakoff, vol.3,
Jai Press, c1994
大学図書館所蔵 全2件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
内容説明・目次
内容説明
Intense interest has been focused on the proliferation and differentiation of cells in multicellular organisms, because these events play a key role in embryogenesis, and coordinate the development and maintenance of the whole body by recruiting the mature cells with specific functions and regulating the formation of organs.
Proteins, called growth factors, are mainly responsible for determining the fate of cells. The actions of growth factors are mediated by their interaction with specific receptors composed of an extracellular ligand-binding portion, a membrane spanning region, and a cytoplasmic region. The most important question is: How is the interaction of a ligand with its receptor transferred through the cytoplasmic membrane into the intracellular machinery that governs cell behavior? Tremendous efforts devoted to cloning growth factor receptors have made it possible to dissect receptor structures into functional domains: a ligand-binding site, a signal transducer region, and a regulatory domain.
The first exciting finding was that receptors for epidermal growth factor (EGF), insulin, insulin-like growth factor (JGF), platelet-derived growth factor (PDGF), and several other growth factors were tyrosine kinases that were regulated by binding to individual specific ligands; the receptors are membrane-associated allosteric enzymes. In addition to the tyrosine kinase receptor family, a new receptor family has recently been found which has no tyrosine kinase domain, but has two characteristic conserved features (two pairs of cysteines and a Trp-Ser-X-Trp-Ser motif) in the extracellular region. Receptors of prolactin, growth hormone, and several hemopoietic growth factors including IL-2, IL-3, IL-5, IL-6, granulocyte colony-stimulating factor (G-CSF), granulocyte/macrophage colony-stimulating factor (GM-CSF), and erythropoietin belong to this new family.
Some chapters selected for this volume deal with two tyrosine kinase receptors (receptors for insulin and hepatocyte growth factor), six receptors (for IL-3, IL-5, IL-6, G-CSF, GM-CSF, and erythropoietin) in a new receptor family, and one unique receptor (IL-1 receptor) that does not belong to any known receptor family. Emphasis on a new receptor family is possible because of remarkable progress in the elucidation of receptor compnents that construct high-affinity ligand binding sites and signal transducers.
Although we are still far from a full understanding of the molecular bases connecting ligand binding with cell behavior, the editors believe that one can appreciate through these authoritative reviews where the field is now and where it is proceeding in the years ahead.
目次
Contents. List of Contributors. Introduction to the Series (A. M. Tartakoff). Preface (Y. Kitagawa and R. Sasaki). The Hepatocyte Growth Factor/C-Met Signaling Pathway (D.P. Bottano, A.M.L. Chan, J.S. Rubin, E. Gak, E. Fortney, J. Schindler, M. Chedid, and S.A. Aaronson). Insulin Receptor (Y. Ebina, H. Hayashi, F. Kanai, S. Kamohara, and Y. Nishioka). Interleukin-3 Receptor: Structure and Signal Transduction (T. Kitamura and A. Myajima). Interleukin-5 Receptor (K. Takatsu). Interleukin-6 Receptor and Signal Transduction (T. Matsuda, T. Nakajima, T. Kaisho, K. Nakajima, and T. Hirano). Receptor for Granulocyte Colony-Stimulating Factor (S. Nagata and R. Fukunaga). Gm-Csf Receptor: Structure, Function, and Signal Transduction (H. Kurata, T. Yokota, A. Miyajima, and K. Arai). Perspectives on the Structure and Mechanisms of Signal Transduction by the Erythropoietin Receptor (S.S. Jones). Interleukin-1 Signal Transduction (J.E. Sims, T.A. Bird, J.G. Giri, and S.K. Dower). Index.
「Nielsen BookData」 より