The role of glia in neurotoxicity
著者
書誌事項
The role of glia in neurotoxicity
CRC Press, c1996
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
It is well established that glial cells represent more than mere passive cytoskeletal support elements of the central and peripheral nervous system. A reciprocal relationship exists between neurons and glia that is vital for mutual differentiation, development, and functioning of both cell types. It also has become apparent that perturbations in glial function may lead to deleterious consequences in juxtaposed neurons. It is therefore possible that neuronal damage induced by chemicals or neuropathic disease involves dissociation of glial-neuronal interactions. The Role of Glia in Neurotoxicity brings together experts in the neurosciences to provide a more complete understanding of the effects of chemicals on nervous system function.
This book explores potential sites of glial-neuronal interactions both in the central and peripheral nervous system, focusing on potential sites of neurotoxicant actions. Text introduces basic aspects of neuroscience, the first step toward understanding the mechanisms at work in normal physiology. The ways in which these processes are disturbed in pathological conditions are discussed. Distinguished authors examine the functional interactions between glial cells and neurons during development, adulthood, and senescence. The roles of glia in the normal CNS and PNS are described. The book offers specific, in-depth examples of directly (via diffusive and cell surface signals) or indirectly (via effects on the extracellular fluid or the blood-brain barrier) mediated glial neurotoxicity.
This reference includes different techniques, conceptual frameworks, and approaches that are currently used in the study of the role of glia in neurotoxicity. This timely review not only presents an excellent overview of the state of the science but also provides direction for future research into the consequences of an altered glial-neuronal unit.
目次
The Role of Microglia in Neurotoxic Injury, W.J. Streit
Role of Radial Glia in Neurotoxic Injury, B.H. Choi
Responses of Oligodendrocytes to Neurotoxins, J.deVellis
Schwann Cells and Their Potential Involvement in Neurotoxic Expression, R.M. LoPachin and E.J. Lehning
Astroglial Responses to Neurotoxins, M.D. Norenberg
Responses of Glia to Alcohol, A.K. Snyder
Astrocytes and Ammonia Neurotoxicity, J. Albrecht
Manganese Neurotoxicity, F.C. Wedler
Lead Neurotoxicity, E. Tiffany-Castiglioni
Metallothioneins, and Physiological and Pathological Consequences of Methylmercury Accumulation in Astrocytes, M. Aschner
Mechanisms of Glial-Mediated Cadmium and Zinc Neurotoxicity, T. Jalonen
MPTP Neurotoxicity, W. Nicklas
Quinolinic Acid Neurotoxicity, R. Schwarcz
Nitric Oxide-Induced Glial Toxicity, J. Merrill and S. Murphy
Gene Expression in Astrocytes after Neural Injury, P.M. Martin and J.P. O'Callaghan
Effects of Toxins on Glia in Relation to Vasogenic and Cytotoxic Edema, H.K. Kimelberg, D. Vitarella, and M. Aschner
Precursor Synthesis and Neurotransmitter Uptake by Astrocytes as Targets of Neurotoxicants, D.L. Martin and R.A. Waniewski
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