Pharmacological effects of ethanol on the nervous system

Bibliographic Information

Pharmacological effects of ethanol on the nervous system

edited by Richard A. Deitrich, V. Gene Erwin

(Pharmacology & toxicology)

CRC Press, c1996

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Includes bibliographical references and index

Description and Table of Contents

Description

This book dissects the effects of ethanol on the major neurotransmitter systems affected by ethanol and correlates these actions with the behavioral consequences. The subject is approached first from the perspective of the neurochemical system and the behaviors resulting from ethanol's effects on that system. The behaviors themselves are discussed in later chapters. Some older theories of the effects of ethanol such as the membrane fluidization hypothesis are evaluated in light of new and updated information. Fetal Alcohol Syndrome (FAS) as well as the structural damage in the brain by long term ethanol exposure are also discussed.

Table of Contents

Introduction, R.A. Deitrich and V.G. Erwin Overview, G. Koob Section I: Effects of Ethanol at the Molecular/Cellular Level Cell Membrane Structure, W.G. Wood, F. Schroeder, R.M. Adibhatla, U. Igbavboa, N.A. Avdulov Calcium Channels, D. Mullikin-Kilpatrick and S.N. Treistman Chloride Channels/GABA, S.J. Mihic and R. A. Harris Glutamate Receptors, B. Tabakoff and P.L. Hoffman Cholinergic Systems, A.C. Collins Phosphorylation, K. T. Eggeman and M.D. Browning G-Proteins, F.Y.G. Lee, Sr. and G.S. Wand Adenosine, T.V. Dunwiddie Neurotensin, V.G. Erwin Peptides, G.R. Siggins, Z. Nie, P. Schweitzer, S. Madamba, S.J. Henriksen Thyrotropin Releasing Hormone, T.J. McCown and G.R. Breese Section II: Behavioral Effects of Ethanol Ethanol Intake, H.H. Samson and C.W. Hodge Initial Sensitivity, L.J. Draski and R.A. Deitrich Acute Tolerance, A.D. Le and J.M. Mayer Dependence and Withdrawal, P. Metten and J.C. Crabbe Ethanol's Acute Effects on Thermoregulation: Mechanisms and Consequences, R. Alkana and A.D. Le Section III: Toxicity of Ethanol in the Central Nervous System Free Radicals, R. Nordmann and H. Rouach Fetal Damage-Mechanisms, W.-J.A. Chen, S.E. Maier, and J.R. West Structural Damage, M.E. Charness Neurological Damage and Stroke, M.E. Hillbom Fetal Damage-Behavior, H.C. Becker

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