Bioavailability in environmental risk assessment
著者
書誌事項
Bioavailability in environmental risk assessment
CRC, c1996
大学図書館所蔵 全12件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references (p. 237-284) and index
内容説明・目次
内容説明
Since bioavailability can alter health risk estimates by a factor of 10, 100 or more, its importance in risk assessment cannot be underestimated. Presenting the basic principles that govern bioavailability and how it is measured, this very unique and timely book fills a void in the existing literature on toxicology and toxicokinetics. It contains clear and concise discussions on the behavior of environmental contaminants and how they reach the bloodstream in living organisms. It also presents an exhaustive review of measured bioavailability factors for environmental contaminants most frequently encountered at contaminated sites.
目次
- Introduction Fundamental Concept of Bioavailability Definition of Bioavailability Unaltered Form Systemic Circulation Relationship Between Extent and Rate of Bioavailability Extent of Bioavailability Bioavailability in Health Risk Assessment Biologically Effective Dose Internal Dose and Average Daily Internal Dose External Dose and Average Daily External Dose Summary Mechanism of Absorption Respiratory System Structure and Function Rate-Limiting Processes for Gaseous Phase Contaminants Other Factors Influencing Respiratory Bioavailability for Gases and Vapors Rate-Limiting Processes for Particulate Phase Contaminants Other Factors Influencing Respiratory Bioavailability for Aerosols Gastrointestinal System Structure and Function Rate-Limiting Processes Other Factors Influencing Oral Bioavailability Skin Structure and Function Rate-Limiting Processes Other Factors Influencing Dermal Bioavailability Summary Experimental Methods for Evaluating Bioavailability General in Vivo Methods Measurement of Blood Levels Measurement of the Cumulative Urinary Excretion Mass-Balance Technique Measurement of Toxic Response Specific Methods for the Inhalation Exposure Route Determination of Deposition Fraction Mechanical Clearance Fraction Dissolution Rate In Vitro Methods: Isolated Perfused Lung Specific Methods for the Ingestion Exposure Route Measurement of Fecal Excretion Measurement of Liver Ratio Dissolution Testing Methods Based on the pH Partition Theory Specific Methods for Dermal Exposure Route Surface Disappearance In Vitro Methods: Biological Membrane Models
- Artificial Membrane Models Summary Exposure Routes and Bioavailability Factors for Selected Contaminants* Arsenic Cadmium Chromium and Chromium Compounds Copper Mercury Lead 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Polynuclear Aromatic Hydrocarbons (PAHs) Benzene Toluene Polychlorinated Phenols Phenol Aniline Bioavailability of Xenobiotics from Contaminated Sites Identification of Exposure Routes Reliability and Validity of the Bioavailability Factors Choice of Experimental Methods Analytical Capabilities Species Differences Mixtures and Vehicles Mechanism of Toxicity Chemical Forms Exposure Duration and Frequency Priority Needs for Further Research Considerations for Applying Bioavailability to Health Risk Assessment Metals Organic Xenobiotics Other Application Considerations Risk Management Considerations References Glossary of Terms Index *For each of the contaminants in this section, the following is provided: Exposure Routes and Receptors Toxicokinetics (Following Absorption) Bioavailability (Inhalation, Ingestion, Dermal) Uncertainties Conclusions Recommendations
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