A textbook of drug design and development
著者
書誌事項
A textbook of drug design and development
Harwood Academic, c1996
2nd ed.
- : pbk
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注記
Previous ed.: 1991
Includes bibliographical references and index
内容説明・目次
内容説明
This work starts with an overview of the topics of drug discovery and follows the individual stages of drug design and development, from the initial elucidation of a structure-activity relationship to the final processes of clincial evaluation and registration. Topics examined include the design of drugs for particular cellular aspects such as ion channels and receptors; specific classes of drug, such as peptidomimetics, antivirals and anticancer agents; the use of gene technology in pharmaceutical research; and the design and application of prodrugs to improve drug delivery.
目次
- Drug discovery - an overview
- structural and phsyicochemical factors in drug action
- computer-aided development of three-dimensional pharmacophore models
- gene technology in pharmaceutical research and production
- receptors
- radiotracers - synthesis and use in imaging
- ion channels
- excitatory amino acid receptors
- enzymes and enzyme inhibitors
- bioinorganic chemistry
- design and application of prodrugs
- peptides and peptidomimetics
- classical antiviral agents and design of new antiviral agents
- anticancer agents
- drug development - from discovery to marketing.
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