Risk and progression factors in carcinogenesis
著者
書誌事項
Risk and progression factors in carcinogenesis
(Recent results in cancer research, 143)
Springer, c1997
大学図書館所蔵 全6件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Cellular transformation and carcinogenesis are considered a multistep process starting with DNA lesions and progressing through loss of cellular growth control and increase invasive and metastatic properties. This book focuses on the demonstration of important steps in carcinogenesis, ranging from chemical interaction of carcinogens with cellular DNA in experimental tumors and cell lines to the analysis of selected human tumors. Special importance is given to the clarification of mechanisms of DNA lesions caused by chemical carcinogens and UV irradiation. Leading scientists describe in review articles the actual state of the art in their specific fields. The reader is informed of trends and scientific approaches to the recognition of pathogenetic mechanisms and factors in malignant tumors.
目次
I. Interaction of Carcinogens with Cellular DNA.- Induction of Frameshift Mutations at Hotspot Sequences by Carcinogen Adducts.- Oxidative DNA Damage Induced by Dioxetanes, Photosensitizing Ketones, and Photo-Fenton Reagents.- Oxidative DNA Damage Profiles in Mammalian Cells.- Chemical Mechanisms of Formation of DNA-Carcinogen Adducts, Elucidation of Potential of Adducts for Mutagenicity, and Mechanisms of Polymerase Fidelity and Mutation in the Presence of Adducts.- Assessment of the Tumor-Initiating Potential of ?,?-Unsaturated Carbonyl Compounds by 32P Postlabeling Quantification of DNA Adducts In Vivo.- Glutathione-Dependent Bioactivation and Renal Toxicity of Xenobiotics.- Ultraviolet-Induced Photolesions: Repair and Mutagenesis.- Psoralen Photobiology: The Relationship Between DNA Damage, Chromatin Structure, Transcription, and Immunogenic Effects.- II. Analysis of Cellular Alterations and Growth Dysregulation in Cancer Cells.- Cellular Stress Response: Stress Proteins - Physiology and Implications for Cancer.- Two-Dimensional Polyacrylamide Gel Electrophoresis of Cancer-Associated Proteins.- Mechanisms Leading to the Expression of Recessive Alleles: The Use of Polymorphic Microsatellites and Whole-Chromosome Painting Probes to Analyze Mouse Tumors, Mtants, and Micronuclei.- Formation of Micronuclei and Inhibition of Topoisomerase II in the Comet Assay in Mammalian Cells with Altered DNA Methylation.- Poly(ADP-Ribosyl)ation and Nuclear Matrix/Intermediate Filament Proteins in Renal Carcinogenesis.- Genotoxic and Chronic Toxic Effects in the Carcinogenicity of Aromatic Amines.- Analysis of Genetic Factors and Molecular Mechanisms in the Development of Hereditary and Carcinogen-Induced Tumors of Xiphophorus.- The Role of Raf Kinases in Development and Growth of Tumors.- Apoptosis Regulation by Raf, Bcl-2, R-Ras.- New Cell Cycle-Regulated Genes in the Yeast Saccharomyces cerevisiae.- The Role of Workhorse Protein Kinases in Coordinating DNA Metabolism and Cell Growth.- III. Selected Findings in Human Tumors.- Growth and Transformation of Human Oral Epithelium In Vitro.- Genetic Lesions in Mantle Cell Lymphoma.- Topoisomerase Activities in Undifferentiated Acute Myeloblastic Leukemias and Monocytic Differentiated Leukemias.- DNA Repair: Genes, Enzymes, Patients, and Mouse Models.- Repair of Directly and Indirectly UV-Induced DNA Lesions and of DNA Double-Strand Breaks in Cells from Skin Cancer-Prone Patients with the Disorders Dysplastic Nevus Syndrome or Basal Cell Nevus Syndrome.- Exploring the Role of Oxygen in Fanconis Anemia.- P53 Gene Alterations in Human Tumors: Perspectives for Cancer Control.
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