Risk and progression factors in carcinogenesis
Author(s)
Bibliographic Information
Risk and progression factors in carcinogenesis
(Recent results in cancer research, 143)
Springer, c1997
Available at 6 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Includes bibliographical references and index
Description and Table of Contents
Description
Cellular transformation and carcinogenesis are considered a multistep process starting with DNA lesions and progressing through loss of cellular growth control and increase invasive and metastatic properties. This book focuses on the demonstration of important steps in carcinogenesis, ranging from chemical interaction of carcinogens with cellular DNA in experimental tumors and cell lines to the analysis of selected human tumors. Special importance is given to the clarification of mechanisms of DNA lesions caused by chemical carcinogens and UV irradiation. Leading scientists describe in review articles the actual state of the art in their specific fields. The reader is informed of trends and scientific approaches to the recognition of pathogenetic mechanisms and factors in malignant tumors.
Table of Contents
I. Interaction of Carcinogens with Cellular DNA.- Induction of Frameshift Mutations at Hotspot Sequences by Carcinogen Adducts.- Oxidative DNA Damage Induced by Dioxetanes, Photosensitizing Ketones, and Photo-Fenton Reagents.- Oxidative DNA Damage Profiles in Mammalian Cells.- Chemical Mechanisms of Formation of DNA-Carcinogen Adducts, Elucidation of Potential of Adducts for Mutagenicity, and Mechanisms of Polymerase Fidelity and Mutation in the Presence of Adducts.- Assessment of the Tumor-Initiating Potential of ?,?-Unsaturated Carbonyl Compounds by 32P Postlabeling Quantification of DNA Adducts In Vivo.- Glutathione-Dependent Bioactivation and Renal Toxicity of Xenobiotics.- Ultraviolet-Induced Photolesions: Repair and Mutagenesis.- Psoralen Photobiology: The Relationship Between DNA Damage, Chromatin Structure, Transcription, and Immunogenic Effects.- II. Analysis of Cellular Alterations and Growth Dysregulation in Cancer Cells.- Cellular Stress Response: Stress Proteins - Physiology and Implications for Cancer.- Two-Dimensional Polyacrylamide Gel Electrophoresis of Cancer-Associated Proteins.- Mechanisms Leading to the Expression of Recessive Alleles: The Use of Polymorphic Microsatellites and Whole-Chromosome Painting Probes to Analyze Mouse Tumors, Mtants, and Micronuclei.- Formation of Micronuclei and Inhibition of Topoisomerase II in the Comet Assay in Mammalian Cells with Altered DNA Methylation.- Poly(ADP-Ribosyl)ation and Nuclear Matrix/Intermediate Filament Proteins in Renal Carcinogenesis.- Genotoxic and Chronic Toxic Effects in the Carcinogenicity of Aromatic Amines.- Analysis of Genetic Factors and Molecular Mechanisms in the Development of Hereditary and Carcinogen-Induced Tumors of Xiphophorus.- The Role of Raf Kinases in Development and Growth of Tumors.- Apoptosis Regulation by Raf, Bcl-2, R-Ras.- New Cell Cycle-Regulated Genes in the Yeast Saccharomyces cerevisiae.- The Role of Workhorse Protein Kinases in Coordinating DNA Metabolism and Cell Growth.- III. Selected Findings in Human Tumors.- Growth and Transformation of Human Oral Epithelium In Vitro.- Genetic Lesions in Mantle Cell Lymphoma.- Topoisomerase Activities in Undifferentiated Acute Myeloblastic Leukemias and Monocytic Differentiated Leukemias.- DNA Repair: Genes, Enzymes, Patients, and Mouse Models.- Repair of Directly and Indirectly UV-Induced DNA Lesions and of DNA Double-Strand Breaks in Cells from Skin Cancer-Prone Patients with the Disorders Dysplastic Nevus Syndrome or Basal Cell Nevus Syndrome.- Exploring the Role of Oxygen in Fanconis Anemia.- P53 Gene Alterations in Human Tumors: Perspectives for Cancer Control.
by "Nielsen BookData"