Molecular toxicology

Author(s)

• Josephy, Philip David
• Mannervik, Bengt
• Ortiz de Montellano, Paul R.

Bibliographic Information

Molecular toxicology

P. David Josephy with Bengt Mannervik and Paul Ortiz de Montellano

Oxford University Press, 1997

Note

Includes bibliographica references and index

Description and Table of Contents

Description

This book presents the biochemical and molecular biological fundamentals underlying toxicology and drug metabolism. It covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expression, and analysis of the enzymes of biotransformation; and molecular toxicology of aromatic amines, nitrosames, polycyclic aromatic hydrocarbons, and chlorinated compounds.

Table of Contents

• Introduction
• 1. Biochemical Background
• 2. Molecular biology and its applications in toxicology
• 3. Biological oxidations
• 4. Superoxide and superoxide dismutase
• 5. Hydrogen peroxide and catalase
• 6. The respiratory burst
• 7. Lipid Peroxidation
• 8. Oxidative stress in the erythrocyte
• 9. Introduction to xenobiotic metabolism
• 10. Clucuronide formation
• 11. Glutathione and detoxication
• 12. Arylamine N-Acetyltransferase
• 13. Sulfotransferase
• 14. Cytochrom P-450
• 15. The AH receptor and the toxicity of chlorinated aromatic compounds
• 16. Identification of DNA adducts
• 17. Chemical mutagenesis
• 18. Carcinogenesis: the genetic targets
• 19. Polycyclic aromatic hydrocarbon carcinogenesis
• 20. Aromatic amines and other N-aryl compounds

by "Nielsen BookData"

• NCID: BA28522298
• ISBN:
  • 0195093402
• LCCN: 95024812
• Country Code: us
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: New York ; Oxford
• Pages/Volumes: xiv, 368 p.
• Size: 26 cm
• Classification:
  • LCC : RA1220.3
  • DC20 : 615.9
• Subject Headings:
  • LCSH : Molecular toxicology