Molecular toxicology
著者
書誌事項
Molecular toxicology
Oxford University Press, 1997
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注記
Includes bibliographica references and index
内容説明・目次
内容説明
This book presents the biochemical and molecular biological fundamentals underlying toxicology and drug metabolism. It covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expression, and analysis of the enzymes of biotransformation; and molecular toxicology of aromatic amines, nitrosames, polycyclic aromatic hydrocarbons, and chlorinated compounds.
目次
- Introduction
- 1. Biochemical Background
- 2. Molecular biology and its applications in toxicology
- 3. Biological oxidations
- 4. Superoxide and superoxide dismutase
- 5. Hydrogen peroxide and catalase
- 6. The respiratory burst
- 7. Lipid Peroxidation
- 8. Oxidative stress in the erythrocyte
- 9. Introduction to xenobiotic metabolism
- 10. Clucuronide formation
- 11. Glutathione and detoxication
- 12. Arylamine N-Acetyltransferase
- 13. Sulfotransferase
- 14. Cytochrom P-450
- 15. The AH receptor and the toxicity of chlorinated aromatic compounds
- 16. Identification of DNA adducts
- 17. Chemical mutagenesis
- 18. Carcinogenesis: the genetic targets
- 19. Polycyclic aromatic hydrocarbon carcinogenesis
- 20. Aromatic amines and other N-aryl compounds
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