Animal models of human related calcium metabolic disorders
著者
書誌事項
Animal models of human related calcium metabolic disorders
CRC Press, c1995
大学図書館所蔵 全2件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This book presents the available experimental models for common human calcium metabolic disorders. It provides valuable information for those planning animal experimental models for common and rare human bone diseases.
Animal Models of Human Related Calcium Metabolic Disorders opens with a description of the major events of bone formation, growth, and remodeling in the human fetus. This is compared to bone formation in rats and mice. Both the normal and abnormal mineralization processes in man and in laboratory animals are described.
Unique to this book are the descriptions of all major skeletal dysplasias known in man and animal experimental models. Of special importance are the detailed experimental models in mice and rats where a variety of hormones and drugs transplacentally induce different types of skeletal injuries which mimic skeletal dysplasias.
The effects of bone-seeking hormones on the skeleton are presented in later chapters as well as a comparison of the effects on human and animal bones, and the relation of the animal models to human growth and osteoporosis. Existing models of osteoporosis, disuse, and senescence osteoporosis are presented in depth. The effects of newly synthesized active bisphosphonates and their potential use in the treatment of human bone diseases are also discussed.
The last chapter describes several animal models of renal bone disease and includes original data on the bone structure in rats with acute and chronic renal failure, and the relevance to the situation in man. Animal Models of Human Related Calcium Metabolic Disorders will prove to be a useful reference to both students and scientists interested in all major aspects of calcium-related disorders.
目次
Comparative Aspects of Cartilage and Bone Formation in Man, Rats, and Mice, A. Ornoy
Normal and Abnormal Primary Mineralization, J. Sela and A. Ornoy
The Congenital Chondrodysplasias: Human Disorders and Related Animal Models, Z. Borochowitz
Osteochondrodysplasias: Clinical Findings in Man and Experimental Animal Models, A. Ornoy
Osteoporosis: Animal Models for the Human Disease, A. Ornoy and S. Katzburg
Glucocorticoid-Induced Bone Changes (Osteopenia), A. Ornoy and S. Katzburg
Estrogen Regulation of Endochondral Bone Formation, Z. Schwartz, J. Meincke, E. Nasatzky, D.D. Dean, and B.D. Boyan
Regulation of Endochondral Bone Formation by Testosterone, Z. Schwartz, E. Nasatzky, J. Meincke, D.D. Dean, and B.D. Boyan
The Evaluation of Bisphosphonates as Potential Drugs for the Treatment of Calcium-Related Disorders, J.M. Van Gelder and G. Golomb
Animal Models of Renal Bone Disease, A. Moskovici, D. Rubiner, M.M. Friedlaender, and M.M. Popovtzer
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