Oral anticoagulants
Author(s)
Bibliographic Information
Oral anticoagulants
Arnold , Oxford University Press, 1996
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Note
Includes index
Description and Table of Contents
Description
Warfarin and related drugs have been used for over half a century in prevention and treatment of thrombotic disorders. Only recently however has their clinical role been firmly established by randomised studies and their benefit/risk ratio improved by lower dose therapy with improvements in laboratory monitoring.
'Oral Anticoagulants' is the first comprehensive, practical survey of the subject available. An international team of recognised experts provide detailed coverage on the mode of action; clinical pharmodynamics; magnitude and sources of variability in individuals response to oral anticoagulant; methods of individualising dosing regimens; laboratory monitoring; and comparison between the different currently prescribed oral anticoagulants.
Table of Contents
Preface
The history of the development of oral anticoagulant drugs
Structure and mechanisms of activation of vitamin K antagonists
Pharmacokinetics and drug interactions with Warfarin
Laboratory monitoring of anticoagulants
Proteins induced by vitamin K absence (PIVKA's)
the effect of coumarins circulating clotting factors
Effects of vitamin K and oral anticoagulants on human bone metabolism
Human recombinant tissue factor. Development and initial studies in monitoring Warfarin
The effects of oral anticoagulants on molecular markers of thrombosis
Oral anticoagulants in the prevention and treatment of venous thromboembolism
Atrial fibrillation and oral anticoagulants
Oral anticoagulants in the secondary and primary prevention of myocardial infarction and coronary death
Valvular heart disease and heart valve prosthesis
Oral anticoagulants for prevention of stroke and cerebral embolism
Practical dosing considerations with Warfarin and optimal therapeutic range
Use of anticoagulants in pregnancy
Hemorrhagic complications or oral anticoagulant therapy
Oral anticoagulation therapy in paediatric patients
Warfarin in the treatment of cancer
Oral anticoagulants in the elderly
Indications and results with combined Warfarin and antiplatelet drugs
Anticoagulation in cardiomyopathy
Rebound hypercoagulability after discontinuation of oral anticoagulants
Index
by "Nielsen BookData"
