Multidrug resistance in cancer cells : molecular, biochemical, physiological, and biological aspects

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Bibliographic Information

Multidrug resistance in cancer cells : molecular, biochemical, physiological, and biological aspects

edited by Sudhir Gupta and Takashi Tsuruo

Wiley, c1996

Available at  / 9 libraries

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Includes bibliographical references and index

Description and Table of Contents

Description

The emergence of resistant cancer cells after repeated courses of chemotherapy is exacerbated by the development of multidrug resistance and has reduced the promise of combination chemotherapy. This book considers the clinical and scientific implications of resistance on cancer treatment.

Table of Contents

CHARACTERIZATION, EXPRESSION AND FUNCTIONS OF TRANSPORTERS IN MDR. Functional and Molecular Characterization of the Human Multidrug Transporter (C. Hrycyna, et al.). Regulation of MDR Genes (M. Cornwell). Chromosomal and Extrachromosomal Localization of Human MDR Genes (P. Schoenlein) The Role of Topoisomerase II in Multidrug Resistance (S. Yamada K. Ando). Non-PKC Kinases and Multidrug Resistance (I. Abraham). REVERSAL OF MULTIDRUG RESISTANCE. Multidrug Resistance-reversing Agents for Potential Clinical Use (O. Nakanishi T. Tsuruo). Reversal of MDR in Solid Tumors (G. Gianccone H. Pinedo). Index.

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