Regulation of body weight : biological and behavioral mechanisms : report of the Dahlem Workshop on Regulation of Body Weight: Biological and Behavioral Mechanisms, Berlin, May 14-19, 1995
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Bibliographic Information
Regulation of body weight : biological and behavioral mechanisms : report of the Dahlem Workshop on Regulation of Body Weight: Biological and Behavioral Mechanisms, Berlin, May 14-19, 1995
（Dahlem workshop reports, . Life sciences research report ; 57）
J. Wiley & Sons, c1996
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"Program advisory committee: C. Bouchard and G.A. Bray, chairpersons, G. Ailhaud ... [et al.]."
"Sponsored by Senat der Stadt Berlin" --Add. t.p
Includes bibliographical references and indexes
Description and Table of Contents
Description
The fact that about 30-40 per cent of the adults in the Western world are overweight or obese testifies to the frequency of the disturbances in body weight regulation. Scientists have established that caloric intake, macronutrient composition of the diet, basal and resting metabolic rate, thermic response to food, energy expenditure associated with movement and physical activity, and preferential storage of the surplus of calories as fat or lean tissues are critical determinants of energy balance and body weight. While much has been learned, the field is poised for major advances with the advent of a variety of imaging techniques, progress in quantitative and molecular genetics, use of transgenic rodent models and of breeding experiments with informative inbred strains, availability of stable isotopes for metabolic and behavioral studies, and a growing number of useful experimental animal and human models. This volume takes an integrative approach to obesity.
It is structured around four major topics: (1) the animal and human models currently available for the study of body weight regulation with their strengths and limitations, (2) the molecular and genetic basis of the regulation of body weight, (3) the metabolic and physiological mechanisms involved, and (4) the behavioral and social determinants. The 13 background papers provide a critical overview of the present knowledge base while the group reports summarize the extensive deliberations of 38 international experts. Particular emphasis has been given to promising research areas and on the advances needed to ensure a better understanding of the biological and behavioral mechanisms of the regulation of body weight, with a particular emphasis on overweight and obesity.
Table of Contents
Animal Models of Hyperphagia (D. York G. Bray). Models of Nutrient Partitioning (M. Stock). Animal Models of the Ageing-Associated Metabolic Syndrome of Obesity (B. Hansen). The Metabolic Syndrome of Human Obesity (L. Sjostrom) Group Report: What are the Animal and Human Models for the Study of Regulation of Body Weight and What Are Their Respective Strenghts and Limitations? Food Intake and Body Weight Regulation (J. Blundell). Physical Activity and Body Weight Regulation (W. Saris). Early Influences on Body Weight Regulation (W. Dietz). Group Report: What Are the Bio-behavioral Determinants of Body Weight Regulation? Peptides in Regulation of Energy Metabolism and Body Weight Metabolic Determinants of Body Weight Regulation (A. Astrup J. Flatt). Molecular and Cellular Determinants of Body Weight Regulation (G. Ailhaud). Group Report: What Are the Metabolic and Physiological Mechanisms Associated with the Regulation of Body Weight? Strategies for Identifying Human Obesity Genes (R. Price). Molecular Genetic Approaches to Complex Traits (J. Friedman). Manipulating the Mouse Germline: Implications for Obesity Research (L. Kozak). Group Report: How Can We Best Apply the Tools of Genetics to Study Body Weight Regulation? Indexes.
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