The neurobiology of puberty

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書誌事項

The neurobiology of puberty

edited by T.M. Plant and P.A. Lee

Journal of Endocrinology, c1995

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注記

Includes bibliographical references and index

"A publication of the Society of Endocrinology"--T.p.

内容説明・目次

内容説明

The control of the timing of puberty in humans remains an important mystery of development. Although the role of the endocrine (hormone) system, and particularly the pituitary and gonadal hormones, in this developmental process is well established, the trigger for the enhanced secretion of these endocrine signals at the onset of sexual maturation is provided by poorly understood brain mechanisms. This text concerns new research that suggests that the endocrinology of childhood and adolescence may be controlled by structural and functional changes in the interconnections between neurons and glial cells in the hypothalamus. The contributors to this book, who are mostly from North America and Europe, cover the latest research in this area, to produce a description of the field. Contributors are drawn from those who presented papers at the Fourth International Conference on the Control of the Onset of Puberty, held in Pittsburgh, USA in September 1994. The book is aimed at clinical endocrinologists and paediatricians and those concerned with growth and sexual development, as well to basic scientists involved in neurobiology or neuroendocrine regulation of the pituitary/gonadal axis.

目次

Part 1: The GnRH neuron - birth, migration, molecular and celluar biology and integrative activity. Part 2: The neurobiology of the pubertal activiation of pulsatile GnRH release. Part 3: The ontogeny of the GnRH pulse generator in higher primates. Part 4: metabolic signals for the onset of puberty. Part 5: Update on therapeutic approaches for the treatment of central precocious puberty. Part 6: Concluding remarks.

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