Molecular diversity and combinatorial chemistry : libraries and drug discovery
著者
書誌事項
Molecular diversity and combinatorial chemistry : libraries and drug discovery
（Conference proceedings series）
American Chemical Society, c1996
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注記
Proceedings of two conferences sponsored by Cambridge Healthtech Institute held at the Hotel Del Coronado, in Coronado, California, January 28-February 2, 1996
Includes bibliographical references and indexes
内容説明・目次
内容説明
Reports progress on chemical, enzymatic, phage, and cell-derived libraries. Discusses synergy between structure-based design and combinatorial libraries. Presents applications of combinatorial libraries to drug discovery and new synthetic catalysis. Reports library screening approaches, including the use of NMR. Presents recent advances in solid-phase organic synthesis, liquid-phase organic synthesis, and high-throughput combinatorial organic synthesis. Discusses
automation of organic synthesis as well as new methodologies for monitoring solid-phase organic synthesis.
目次
- Secondary Structure Templated Libraries: Mimicking Nature
- Construct Diversity: A New Paradigm for Combinatorial Chemistry
- Enhancing the Drug Discovery Process by Integration of High-Throughput Chemistry and Structure-Based Drug Design
- Phosphorus as a Scaffold: Combinatorial Libraries of Non-nucleotide Phosphoramidates
- Convergent Solid-Phase Synthesis of Phosphoramidate Combinatorial Libraries
- Solid-Phase Synthesis, Characterization, and Screening of a 43,000-Compound Tetrahydroisoquinoline Combinatorial Library
- Solid-Phase and Combinatorial Synthesis of Heterocyclic Scaffolds: Dihydropyridines, Pyridines, and Pyrido [2,3-d]pyrimidines
- Polymer-Supported Chemistry: Synthesis of Small-Ring Heterocycles
- A Solution-Phase Strategy for the Parallel Synthesis of Chemical Libraries Containing Small Organic Molecules: A General Dipeptide Mimetic and a Flexible General Template
- Structurally Homogeneous and Heterogeneous Libraries: Scaffold-Based Libraries and Libraries Built Using Bifunctional Building Blocks
- Liquid-Phase Combinatorial Synthesis
- Libraries of Transition-Metal Catalysts: High-Throughput Screening of Catalysts for Synthetic Organic Methodology
- Mixtures of Molecules Versus Mixtures of Pure Compounds on Polymeric Beads
- Generation of Solution-Phase Libraries of Organic Molecules by Combinatorial Biocatalysis
- Living Libraries Using Gene Transfer: A Renaissance for Natural Products
- Phage Expression of a De Novo Designed Coiled Coil Stem Loop Miniprotein Scaffold for Constrained Peptide Library Display
- Automation of High-Throughput Synthesis: Automated Laboratory Workstations Designed to Perform and Support Combinatorial Chemistry
- Boosting the Productivity of Medicinal Chemistry Through Automation Tools: Novel Technological Developments Enable a Wide Range of Automated Synthetic Procedures
- A Modular System for Combinatorial and Automated Synthesis
- LiBrain: Software for Automated Design of Exploratory and Targeted Combinatorial Libraries
- Automation Issues at the Interface Between Combinatorial Chemistry and High-Throughput Screening
- Tools for Combinatorial Chemistry
- Magic-Angle Spinning NMR Spectroscopy of Polystyrene-Bound Organic Molecules: Monitoring a Three-Step Solid-Phase Synthesis Involving a Heck Reaction
- A High-Throughput Functional Assay for G-Protein-Coupled Receptors: Method for Screening Combinatorial Libraries
- Use of Combinatorial Libraries in the Discovery and Development of Novel Anti-infectives
- Application of Polymer-Supported Chemistry to the Discovery and Optimization of Lead Drug Candidates
- Using Pharmacophore Diversity To Select Molecules To Test from Commercial Catalogues
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