Antibody engineering
著者
書誌事項
Antibody engineering
（Chemical immunology, 65）
Karger, 1997
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The last decade has witnessed remarkable developments in antibody research and its therapeutic applications. With the methods of molecular biology it is now possible to manipulate the specificities and activities of antibody molecules to generate an almost limitless array of structures for both basic investigations and the clinical setting. The contributions to this volume cover all three domains of the antibody: the variable regions, the relatively neglected but crucial hinge, and the constant region. These studies provide critical structural and functional information about antibodies, while also pointing the way to the construction of molecules with enhanced or even novel properties. Bringing together major experts on antibody engineering, this book is highly recommended to faculty, postdoctoral fellows and graduate students in molecular biology, microbiology, immunology, cancer research and genetics.
目次
- Engineering minibody-like ligands by design and selection, M. Sollazzo et al
- Antibodies against HIV-1 from phage display libraries - mapping of an immune response and progress towards antiviral immunotherapy, P.W.H.I. Parren, D.R. Burton
- Chemical engineering at the antibody hinge, G.T. Stevenson
- Structure and function in IgA, J.M. Hexham et al
- IgH effector mechanisms, M.R. Clark
- Glycosylation of antibody molecules - structural and functional significance, R. Jefferis, J. Lund
- Engineering novel antibody molecules, M.G. Sensel et al
- Ligand function of antigenized antibodies expressing the RGD motif, R. Billetta et al
- Immunogenecity of viral epitopes expressed on genetically and enzymatically engineered immunoglobulins, C.A. Bona et al.
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