c-Myc function in neoplasia
Author(s)
Bibliographic Information
c-Myc function in neoplasia
(Medical intelligence unit)
Springer-Verlag , R.G. Landes, c1995
- :U.S. and Canada
- :International
Available at 1 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Includes bibliographical references and index
Description and Table of Contents
Description
1. 1 SCOPE OF BOOK n explosion of novel findings in the past decade has contrib- A uted to the great progress toward understanding the biology of human cancers. Much of this progress can be attributed to our abil- ity to dissect many biological processes at the molecular level. Most spectacular is the technology of molecular biology that allows identi- fication and characterization of genes that participate in the genesis of human cancers. Three major groups of genes appear to play out the drama of cancer development: tumor suppressor genes, mis- match repair genes, and oncogenes. The tumor suppressor genes 1 encode products that are inhibitory to cell proliferation. The loss of these inhibitors, by mutation or deletion, can unleash cells from their restraints to proliferate. Mutations in the mismatch repair 2 10 genes also have been implicated in tumorigenesis. - The inability of cells to repair spontaneously occurring mutations leads to genom- ic instability and could potentially result in the accumulation of car- cinogenic DNA lesions. Finally, activation of proto-oncogenes, which are normal cellular genes, into oncogenes could accelerate the 11 processes of cell proliferation. c-myc was one of the very first proto- oncogenes to be identified and because it normally plays pivotal roles in both cell proliferation and cell death has enticed many to investigate the molecular mechanisms by which it transforms cells.
Table of Contents
1. Introduction.- 2. Retroviruses, Cancer Genes, and Tumor Suppressor Genes.- 3. Historical Perspectives of myc Gene Studies.- 4. Structure of the c-myc Gene and Its Transcription.- 5. Involvement of c-myc in Human Cancers.- 6. Properties of the c-Myc Protein.- 7. Functional Domains of c-myc Protein.- 8. Max Association with Myc.- 9. DNA-Binding Properties of Myc.- 10. Myc Target Genes in Cell Proliferaion and Programmed Cell Death.
by "Nielsen BookData"