Nitric oxide research from chemistry to biology : EPR spectroscopy of nitrosylated compounds
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Bibliographic Information
Nitric oxide research from chemistry to biology : EPR spectroscopy of nitrosylated compounds
（Molecular biology intelligence unit）
Landes , Springer, c1997
- : International
- : us and cn
- Other Title
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EPR spectroscopy of nitrosylated compounds
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Digital Library of Nara Institute of Science and Technology
:International ISBN464.1||MOL||1250021995
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Note
Includes bibliographical references and index
Description and Table of Contents
- Volume
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: us and cn ISBN 9780412135613
Table of Contents
Prologue.- Introducing the VIDM Club.- A Beautiful Molecule.- 1. Introduction: The Origins of Nitric Oxide.- Nitrogen Cycles.- Sources of Nitric Oxide, an Air Pollutant.- Use of Nitric Oxide as a Paramagnetic Probe of Metalloproteins.- Nitric Oxide in Bacterial Denitrification.- Effects of Exogenous Nitric Oxide on Humans.- Nitric Oxide Biosynthesis in Mammals.- Introductory Chapters.- Scaling Problems in the Quantification Methods of Nitric Oxide.- A Historical Note.- Additional Recent Bibliography.- 2. Basic Chemistry of Nitric Oxide and Related Nitrogen Oxides....- Structure of Nitrogen Oxides.- Reactivity of Nitric Oxide and Nitrogen Oxides.- 3. Basic EPR Methodology.- Basic Principles of EPR Spectroscopy.- Experimental Conditions.- Discussion: Specificity Versus Sensitivity.- 4. EPR Characterization of Nitric Oxide Binding to Hemoglobin.- Nitrosyl Hemoglobin: Kinetic and EPR Data.- Reactions of Nitric Oxide with Ferrihemoglobin and Oxyhemoglobin.- Conclusion.- 5. Effects of Nitric Oxide on Red Blood Cells.- Effects of Long-Term Exposure of Animals and Humans to Nitric Oxide and Nitrogen Dioxide Gas Considered as Air Pollutants.- Effects of Nitrite and Nitrogenous Vasodilators on Red Blood Cells.- Effects on Red Blood Cells of Nitric Oxide Inhalation in Therapeutic Uses.- Conclusions.- 6. Utilization of Nitric Oxide as a Paramagnetic Probe of the Molecular Oxygen Binding Site of Metalloenzymes.- Hemoproteins.- Cytochrome c Oxidase (Cytochrome aa3).- Copper-Containing Proteins.- Mononuclear Iron-Containing Dioxygenases.- [FeS], Ni and Mo Cluster-Containing Proteins.- Binuclear Iron-Containing Proteins.- Conclusion.- 7. Nitric Oxide, an Intermediate in the Denitrification Process and Other Bacterial Pathways, as Detected by EPR Spectroscopy.- Introduction: A Historical Background.- Respiratory and Assimilatory Nitrite Reductases.- Nitric Oxide Reductases.- Other Cytochromes Interacting with Nitric Oxide.- Nitrous Oxide Reductases.- Possible Roles of Nitric Oxide in Nitrification and Nitrogen-Fixation.- Bacterial Nitric Oxide Synthase.- Discussion and Conclusion.- 8. Nitric Oxide Biosynthesis in Mammals.- Constitutive and Inducible Nitric Oxide Synthases.- Enzymatic Mechanism of Nitric Oxide Synthases.- Nitric Oxide Synthases' Regulations.- Post-Transcriptional Modifications of the Enzyme.- Conclusion.- 9. The Use of EPR Spectroscopy for the Identification of the Nature of Endothelium-Derived Relaxing Factor.- The Nature of Endothelium-Derived Relaxing Factor: A Controversy.- Nitric Oxide as an EDRF Detected by EPR Spectroscopy.- Fe(SR)2(NO)2 Ternary Iron Complexes as Plausible EDRF or Nitric Oxide Transporters.- Conclusion.- 10. Enzymatic Targets of Nitric Oxide as Detected by EPR Spectroscopy Within Mammal Cells.- Soluble Guanylate Cyclase.- [FeS] Cluster-Containing Enzyme.- Ribonucleotide Reductase.- Proteins of the Iron Metabolism.- Conclusion.- 11. Overproduction of Nitric Oxide in Physiology and Pathophysiology: EPR Detection.- Cancer and Interleukin-2 Immunotherapy.- Parasites, Fungi and Bacterial Infections.- Septic Shock.- Autoimmune Diseases.- Organ Transplantations.- Vascular Diseases.- Other Physiological and Pathophysiological States.- Conclusion.- 12. Palliatives to Underproduction of Nitric Oxide as Assayed by EPR Spectroscopy.- Metal Complexes as Nitric Oxide Donors.- Nitrite, Organic Nitrites and Nitrates.- Other Derivatives.- Inhalation Of Nitric Oxide: NO Gas, a Suppletive Drug.- Conclusion.- 13. Nitric Oxide-Specific Spin-Trapping EPR Methods.- Use of Hemoglobin as a Nitric Oxide Spin-Trap.- Conventional Spin-Trapping.- Prospects on Nitric Oxide-Specific Spin-Traps.- Scavenging of Nitric Oxide by Reaction with Stable Free Radicals.- Line Broadening of Fusinite and Other Free Radicals by Nitric Oxide.- Use of Fe-(DETC)2 and Similar Complexes as Nitric Oxide Spin-Traps.- Conclusion.- 14. General Discussion: Crossregulations of Metalloenzymes Triggered by Nitric Oxide.- Downregulation of Nitric Oxide Synthase by Nitric Oxide.- Inhibition of Microsomal Cytochromes P-450.- The Urea Cycle.- Inhibition or Regulation of Cytochrome c Oxidase.- Crossregulations of Other Inducible Metalloproteins.- Regulation by Nitric Oxide of Other Metalloenzymes of the Inflammatory Response.- Other Targets.- General Conclusion.
- Volume
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: International ISBN 9783540617648
Description
This study focuses on the use of electron paramagnetic resonance (EPR) spectroscopy of nitrosylated metalloproteins complexes in nitric oxide research. The basic chemical reactivity and physical properties of nitric oxide are summarized. The use of EPR spectroscopy detection of nitrosylated metalloproteins in cell cultures, in animal models of pathologies, and its potentialities for understanding health-disease switches in humans, are discussed. Standing orders placed on the book before December 31st, 1996 will receive a 10% reduction off the list price of all volumes published within the series (Medical intelligence unit) between the order date and December 31st, 1997.
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