Principles of antineoplastic drug development and pharmacology
Author(s)
Bibliographic Information
Principles of antineoplastic drug development and pharmacology
（Basic and clinical oncology, 9）
M. Dekker, c1996
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
Reviews the principles of drug development and clinical pharmacology applicable to all classes of anticancer drugs. Covers every aspect of drug development--from drug discovery to approval and routine use. Details how the successful application of pharmacological principles can improve drug delivery, individualized dosing, and the circumvention of drug resistance; elucideates proven strategies for widening the therapeutic margin between antitumor effects and severe toxicity; and more.
Table of Contents
Principles of Drug Development
Cancer Drug Screening, Michael R. Grever
The Human Tumor-Cloning Assay, Axel-R. Hanauske, Susan G. Hilsenbeck, and Daniel D. Von Hoff
Phase I Clinical Trial Design, Rosemarie Mick
The New Drug Approval Process: Clinical and Regulatory Aspects, Renzo Canetta
Development of Biological Agents, Rosemary Mazanet, Mary Ann Foote, and George Morstyn
Principles of Antineoplastic Pharmacology
Clinical Pharmacology of Anticancer Drugs, B. W. Berry and Charles Erlichman
Principles of Pharmokinetics and Pharmacodynamics, Mark J. Ratain and Rosemary Mick
Biochemical Modulation of Cancer Chemotherapy, George A. Sotos and Carmen J. Allegra
Drug Interactions in Cancer Chemotherapy, Francois Lokiec
Drug-Radiation Interactions, Everett E. Vokes
Principles of Chemotherapy Interaction with Biological Agents, Mario Sznol, Christine L. Carter and Dan L. Longo
Hematopoietic Growth Factors and Cancer Chemotherapy, Michael S. Gordon
Dose Intensity, William M. Hryniuk
Principles of Chemotherapy Dosing
Polymorphic Drug-Metabolizing Enzymes, Zhihong Lu and Robert B. Diasio
Human Cytochrome P-450, Frank J. Gonzalez
Cellular Pharmacodynamics of Anticancer Drugs, Peter J. O'Dwyer, Thomas C. Hamilton, Kang-Shen Yao, Robert F. Ozols, and James M. Gallo
Cancer Chemotherapy in the Elderly, Maurice Schneider
Cancer Chemotherapy and Pharmacology in Children, Steven Weitman and Barton A. Kamen
Adaptive Control of Drug Dosage Regimens: Basic Concepts, Relevant Issues, and Clinical Applications, Roger W. Jelliffe
Individualized Dosing of Anticancer Drugs, Alan V. Boddy and A. Hilary Calvert
Principles of Drug Resistance
Multidrug Resistance, Ahmad R. Safa
DNA Topoisomerases and Tumor Cell Resistance to Their Inhibitors, William T. Beck
The Glutathione System and Drug Resistance, Gerald Batist, Robyn L. Schecter, and Moulay A. Alaoui-Jamali
Importance of DNA Repair in Cancer Chemotherapy, M. Eileen Dolan
Resistance to Antimetabolites, Godefridus J. Peters and Gerrit Jansen
Principles of Drug Delivery
Targeted Drug Delivery, Pramod K. Gupta, John B. Cannon, and Anil Kumar Tibrewal
Intra-Arterial Chemotherapy, William D. Ensminger
Intraperitoneal Chemotherapy, Maurie Markman
Intrathecal Chemotherapy, Susan M. Blaney and David G. Poplack
Systemic Infusional Chemotherapy, Jacob J. Lokich and Norwood Anderson
Circadian Pharmacodynamics, William J. M. Hrushesky, Robert de W. Marsh, and Patricia A. Wood
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