Discovering molecular genetics : a case study course with problems & scenarios

書誌事項

Discovering molecular genetics : a case study course with problems & scenarios

Jeffrey H. Miller

Cold Spring Harbor Laboratory Press, 1996

大学図書館所蔵 件 / 21

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注記

Includes bibliographical references and indexes

内容説明・目次

内容説明

This textbook offers teachers a one-semester course in molecular genetics for use by life science majors (microbiology, biochemistry, molecular biology or biology) or pre-med students. The book is the syllabus for a course in molecular gentics given by the author at the University of California at Los Angeles, USA, for several years. It adopts a case-study approach, based on analysis of classic and recent papers and discussion of the lives of the principal investigators concerned. The book contains introductory essays which review the key concept in each course unit, over 180 questions and answers which test factual knowledge derived from each unit, and over 140 problems, including scenarios from history, mythology, films and television, which test students' abilities to apply molecular genetic concepts. Solutions and strategies for working out these problems are provided in the companion book, "Solutions Manual and Workbook".

目次

  • Part 1 Classical papers: historical perspective
  • the structure of DNA, Watson and Crick. The fine structure of the gene: Benzer's study of the fine structure of the gene. The nature of the genetic code: general nature of the genetic code for proteins, Crick et al. Decoding the amber and ochre triplets: the nature of nonsense codons
  • deciphering amber and ochre triplets, Brenner at al. The search for colinearity: on the colinearity of gene structure and protein structure, Yanofsky et al. Conjugation and genetic recombination: nature of gene transfer in bacterial conjugation, Wollman et al. Genetic regulatory mechanisms: genetic regulatory mechanisms in the synthesis of proteins, Jacob et al. In vivo genetic engineering: transposition of the lac genes
  • prophage lambda at unusual chromosomal locations, Beckwith et al. Structure-function relationships in proteins: studies of Hemoglobin, Perutz et al. Part 2 Updated papers. Mutagenesis: hotspots for deletions and frameshifts
  • the specicifity of mutagens, Farabaugh et al. Transposable elements: characterization of transposition
  • use of transposons as mutagenic agents
  • mechanism of transposition, Hedges et al. Part 3 Questions, answers, problems and scenarios.

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